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In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant

SHENG, LI
http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233

Abstract Details

, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Age-related macular degeneration (AMD) is one of the leading causes of blindness among people above age of 50 in United States. Retinylamine is a promising visual cycle inhibitor in treating dry AMD. As a vitamin A derivative, retinylamine solves the problem of blood-ocular barrier, however, its instability and toxicity both limit its application in AMD treatment. Polylactic acid (PLA) is widely used biodegradable polymer material for drug-loading implant. In this study, a biodegradable PLA-based retinylamine-loading implant is introduced in order to achieve an effective long-time release of retinylamine on dry AMD murine model Abca4-/-Rdh8-/- mice.
Zheng-Rong Lu (Committee Chair)
Akiko Maeda (Committee Member)
Eben Alsberg (Committee Member)
Biomedical Engineering

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Citations

  • SHENG, L. (2015). In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233

    APA Style (7th edition)

  • SHENG, LI. In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant. 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233.

    MLA Style (8th edition)

  • SHENG, LI. "In Vitro and in Vivo Long-Term Release of Injectable 3-Branch PLA-Retinylamine Conjugate Implant." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1446220233

    Chicago Manual of Style (17th edition)

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© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.