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PROTEOME CHARACTERIZATION OF CAENORHABDITIS ELEGANS DURING DEVELOPMENTAL STAGES

Zaidi, Asifa Khatoon
http://orcid.org/0000-0003-4515-1390
http://rave.ohiolink.edu/etdc/view?acc_num=case1459460612

Abstract Details

2016, Master of Sciences, Case Western Reserve University, Systems Biology and Bioinformatics.
The goal of the present proteomic study on Caenorhabditis elegans is to determine the appearance rates of newly synthesized proteins at the individual protein level during different developmental stages and to identify differentially expressed proteins during development under nutritional stress. Our SILAC-based proteomic approaches revealed that proteins with rapid appearance rates belong primarily to metabolic processes in all developmental stages. We also found that the expressions of proteins involved in normal metabolic processes such as translation, fatty acid synthesis and glycolysis/gluconeogenesis decrease during development under nutritional stress, while proteins involved in calorie regulation and structural molecular activity including proteins involved in fatty acid degradation and highly active fermentative pathways increase. These results provide new insights into the physiological changes of Caenorhabditis elegans proteome during development under normal and nutritional stress.
Masaru Miyagi (Committee Chair)
David Lodowski (Committee Member)
Gurkan Bebek (Committee Member)
185 p.
Bioinformatics; Biology
proteome; Caenorhabditis elegans; mass spectrometry

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Citations

  • Zaidi, A. K. (2016). PROTEOME CHARACTERIZATION OF CAENORHABDITIS ELEGANS DURING DEVELOPMENTAL STAGES [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1459460612

    APA Style (7th edition)

  • Zaidi, Asifa. PROTEOME CHARACTERIZATION OF CAENORHABDITIS ELEGANS DURING DEVELOPMENTAL STAGES. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1459460612.

    MLA Style (8th edition)

  • Zaidi, Asifa. "PROTEOME CHARACTERIZATION OF CAENORHABDITIS ELEGANS DURING DEVELOPMENTAL STAGES." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459460612

    Chicago Manual of Style (17th edition)

case1459460612
337
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.