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Helly Einisman.pdf (6.03 MB)

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S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model

Einisman, Helly J
http://orcid.org/0000-0002-5752-3836
http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615

Abstract Details

2016, Master of Sciences, Case Western Reserve University, Clinical Research.
Bronchopulmonary dysplasia (BPD) is the most common respiratory sequela of prematurity. No strategy successfully reduces its incidence and no treatment solves it absolutely. The activity of S-nitrosoglutathione reductase (GSNOR), the enzyme that degrades GSNO (endogenous bronchodilator), is higher in the lungs of BPD comparing to control mice. In an attempt to find a new target to prevent or treat BPD, we focused on GSNOR in studies using BPD wild-type (WT) mice and GSNOR knockout (KO) mice, in which we also used a GSNOR inhibitor. Major findings were: (1) intrapulmonary bronchioles (IPB) of BPD WT mice were more responsive to methacholine and less responsive to GSNO than WT controls, (2) GSNO elicited equivalent bronchodilation in control and BPD GSNOR KO mice, and (3) pretreatment with a GSNOR inhibitor normalized the bronchodilator efficacy of GSNO in IPB from WT BPD mice. These findings suggest that GSNOR inhibitors are potential therapeutics for BPD.
Stephen Lewis (Committee Chair)
Benjamin Gaston (Committee Member)
Raffay Thomas (Committee Member)
48 p.
Medicine
Bronchopulmonary dysplasia; S-nitrosoglutathione; GSNO; GSNO reductase; GSNOR; GSNOR inhibitor

Recommended Citations

Citations

  • Einisman, H. J. (2016). S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615

    APA Style (7th edition)

  • Einisman, Helly. S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615.

    MLA Style (8th edition)

  • Einisman, Helly. "S-nitrosoglutathione Reductase as a Molecular Target to Prevent Bronchopulmonary Dysplasia in a Murine Model." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1464872615

    Chicago Manual of Style (17th edition)

case1464872615
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© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.