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CRSP Thesis - JBeach format FINAL.pdf (2.8 MB)

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Survival following fenestrated endovascular aortic repair - implications for decision making

Beach, Jocelyn M
http://orcid.org/0000-0003-3048-0343
http://rave.ohiolink.edu/etdc/view?acc_num=case1465492151

Abstract Details

2016, Master of Sciences, Case Western Reserve University, Clinical Research.
Objective: To identify risk factors for death following fenestrated/branched endovascular aortic repair (FEVAR) of thoracoabdominal aneurysms to guide decision making in who will benefit from prophylactic repair. Methods: We evaluated 1091 patients in a prospective investigational device exemption trial who underwent FEVAR. Multivariable analysis of risk factors for death was performed using parametric analysis in multiple-hazard domain and a non-parametric analysis using random-forest technology. Results: Operative mortality is low (3.7%), though 5-year survival is 46.2%. Older patients with heart failure, COPD, renal disease, anemia, and coagulation disorders are at significantly increased risk for death after repair. Risk is highest those undergoing type I/II TAAA repairs with larger aneurysms. Conclusions: FEVAR offers improved survival as compared to the natural history of untreated TAAA. Operative mortality is lower than that reported for open repair, even in this high-risk population. Extending the use of FEVAR in lower risk TAAA patients should be investigated.
Eugene Blackstone, MD (Committee Chair)
Douglas Einstadter, MD (Committee Member)
James Spilsbury, PhD, MPH (Committee Member)
Matthew Eagleton, MD (Other)
80 p.
Medicine; Statistics; Surgery
aortic aneurysm; fenestrated; endovascular; FEVAR; survival; vascular surgery

Recommended Citations

Citations

  • Beach, J. M. (2016). Survival following fenestrated endovascular aortic repair - implications for decision making [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1465492151

    APA Style (7th edition)

  • Beach, Jocelyn. Survival following fenestrated endovascular aortic repair - implications for decision making. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1465492151.

    MLA Style (8th edition)

  • Beach, Jocelyn. "Survival following fenestrated endovascular aortic repair - implications for decision making." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1465492151

    Chicago Manual of Style (17th edition)

case1465492151
374
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.