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Doctoral Dissertation_Ying Gao.pdf (2.15 MB)

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Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging

Gao, Ying, Gao
http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997

Abstract Details

2017, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Preclinical magnetic resonance imaging (MRI) is critical in the investigation of pathophysiology and therapies. High-field (>= 4.7 T) preclinical MRI scanners have been developed to quantitatively evaluate disease status and the efficacy of novel therapies in a wide variety of rodent models with rigorous validation. High magnetic fields provide increased signal-to-noise ratio (SNR) that can be “traded” for spatial / temporal resolution which is extremely valuable in preclinical imaging. However, high-field preclinical MRI systems also face challenges that affect imaging quality, in which B0 inhomogenieties are a major source of artifacts and entail difficulties of conventional clinical acquisitions in low-field settings applied at high fields. In this work, three MRI techniques were developed for high-field preclinical MRI scanners exploiting a fast imaging with steady-state free precession (FISP) acquisition scheme as a technical core to circumvent the significant off-resonance artifacts on high field MRI scanners. First, a FISP-based Look-Locker T1 measurement was developed as a non-invasive and sensitive imaging marker to quantitatively assess autosomal recessive polycystic kidney disease (ARPKD) liver disease in the PCK rat model of ARPKD. Second, a rapid and quantitative arterial spin labeling (ASL)-FISP technique was developed for high-field preclinical MRI scanners to provide perfusion-weighted images in less than 2 s with minimal image artifacts and further investigated in neuroimaging. Third, an initial preclinical 7 T MRI implementation of the highly novel magnetic resonance fingerprinting (MRF) methodology was developed and in vivo preclinical MRF results in mouse kidneys and brain tumor models demonstrated an inherent resistance to respiratory motion artifacts as well as sensitivity to known pathology. Overall, FISP-based quantitative MRI techniques developed here will create a wealth of opportunities for preclinical imaging applications and inform future clinical imaging studies.
Efstathios Karathanasis (Committee Chair)
Chris Flask (Advisor)
Xin Yu (Committee Member)
Vikas Gulani (Committee Member)
Mitchell Drumm (Committee Member)
114 p.
Biomedical Engineering

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Citations

  • Gao, Gao, Y. (2017). Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997

    APA Style (7th edition)

  • Gao, Gao, Ying. Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging. 2017. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997.

    MLA Style (8th edition)

  • Gao, Gao, Ying. "Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging." Doctoral dissertation, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997

    Chicago Manual of Style (17th edition)

case1475150834919997
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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.