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Thao Nguyen Dissertation.pdf (2.09 MB)

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Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease

Nguyen, Thao
http://rave.ohiolink.edu/etdc/view?acc_num=case1481214131475915

Abstract Details

, Doctor of Philosophy, Case Western Reserve University, Pathology.
Antiretroviral therapy administration has nearly eliminated acquired immune deficiency syndrome (AIDS) -related mortality in human immunodeficiency virus (HIV) infected patients. Despite ART mediated reduction of viral replication, there is increased risk of non-AIDS related morbidities in person who fail to recover circulating CD4 T cell counts. These persons are referred to here as “immune failure” (IF) patients. IF subjects exhibit increased immune activation and expression of immune modulating cytokines, type 1 interferons (IFN-I), transforming growth factor-ß (TGF-ß), interleukin-1ß (IL-1ß) and interleukin-6 (IL-6). Homeostatic proliferation in response to interleukin-7 (IL-7) is important to CD4 T cell recovery. Responsiveness to IL-7 may be diminished in IF patients. Diminished responsiveness to IL-7 may be partially related to increased CD4 T cell exposure to IFN-I in IF subjects. In chapter 2, we demonstrate that IFN-a, the primary IFN-I subtype in HIV-infection, inhibits IL-7-induced proliferation in CD4 T cells from HIV uninfected donors. In chapter 3, we show that responsiveness to IL-7 but not IFN-a is impaired in CD4 T cells from IF subjects. In chapter 4, we demonstrate that TGF-ß inhibits IL-7 induced proliferation in memory but not naive CD4 T cells in HIV uninfected donors.
Scott Sieg (Advisor)
Immunology

Recommended Citations

Citations

  • Nguyen, T. (n.d.). Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1481214131475915

    APA Style (7th edition)

  • Nguyen, Thao. Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1481214131475915.

    MLA Style (8th edition)

  • Nguyen, Thao. "Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease." Doctoral dissertation, Case Western Reserve University. Accessed MAY 15, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1481214131475915

    Chicago Manual of Style (17th edition)

case1481214131475915
116
© , some rights reserved.Creative Commons License Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease by Thao Nguyen is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.