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Mi Zhang_Thesis Feb 11 2019.pdf (2.94 MB)
ETD Abstract Container
Abstract Header
Engineering In Vitro Vascularization On A Chip
Author Info
Zhang, Mi
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1549976951359121
Abstract Details
Year and Degree
2019, Master of Sciences, Case Western Reserve University, Chemical Engineering.
Abstract
Vascularization in vitro, the process of forming 3-D microvessels, is a key challenge in making regenerated tissue feasible and sustainable for tissue engineering. Recent hydrogel modeling has facilitated the construction of in vitro vascular network models, yet the formation and understanding the dynamics of the sprouting process during vascularization is still unclear. In this investigation, we studied the ability of human breast cancer cells to induce migration and vascularization of human endothelial cells in two in vitro models. Enhanced cell migration was observed in the presence of cancer cells in a simple annular device. Subsequently, we fabricated and demonstrated vascular network formation in a microfabricated device containing spheroidal tissue models of human fibroblasts and breast cancer cells. Collectively, our results showed that the endothelial cell migration and vascularization are greatly enhanced by the presence of cancer cells.
Committee
Harihara Baskaran (Advisor)
Pages
82 p.
Subject Headings
Chemical Engineering
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Citations
Zhang, M. (2019).
Engineering In Vitro Vascularization On A Chip
[Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1549976951359121
APA Style (7th edition)
Zhang, Mi.
Engineering In Vitro Vascularization On A Chip.
2019. Case Western Reserve University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1549976951359121.
MLA Style (8th edition)
Zhang, Mi. "Engineering In Vitro Vascularization On A Chip." Master's thesis, Case Western Reserve University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1549976951359121
Chicago Manual of Style (17th edition)
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Document number:
case1549976951359121
Download Count:
115
Copyright Info
© 2019, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.