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Gene Expression Profiling of Fatigue in Individuals with End Stage Renal Disease

Horvat Davey, Christine Marie
http://orcid.org/0000-0002-3686-4391
http://rave.ohiolink.edu/etdc/view?acc_num=case1564493520748895

Abstract Details

2019, Doctor of Philosophy, Case Western Reserve University, Nursing.
Fatigue is a prevalent and challenging symptom experienced by individuals with end stage renal disease (ESRD) on hemodialysis. Fatigue is associated with decreased quality of life, increased risk for cardiovascular events, and increased mortality rates in individuals with ESRD, though causes of fatigue in individuals with ESRD remains poorly understood. We examined the gene expression of NPAS2 in relation to the self-report experience of fatigue in one-hundred and twenty-two individuals with ESRD. Gene expression was examined utilizing quantitative Polymerase Chain Reaction (qPCR). Patient self-reported fatigue was examined utilizing the Fatigue Assessment Scale (FAS) and Functional Assessment of Chronic Illness Therapy – Fatigue Scale (FACIT-F). Independent samples t-tests were used to determine the extent to which gene expression of NPAS2 attributes to the phenotypic characteristic of fatigue. Multivariable regression analyses were used to determine the relationship between the phenotype of fatigue and demographic variables (age, sex, race, education level, marital status, and employment), dialysis factors (cause of and years with ESRD, time of hemodialysis session, and hours of dialysis per session), comorbid health conditions, sleep quality, Body Mass Index (BMI), and depression. One hundred twenty-two individuals completed the study. Participants were approximately 58 years old (+/- 13.2), 78% African American (n=95), and 72% male (n=88). No association was found between gene expression of NPAS2 and fatigue in this patient population. Of the variables examined, depression was the only significant predictor of fatigue.
Allison Webel, PhD (Committee Chair)
Joachim Voss, PhD (Committee Member)
Chao-Pin Hsiao, PhD (Committee Member)
Federico Perez, PhD (Committee Member)
Genetics; Nursing
end stage renal disease, fatigue, gene expression, depression

Recommended Citations

Citations

  • Horvat Davey, C. M. (2019). Gene Expression Profiling of Fatigue in Individuals with End Stage Renal Disease [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1564493520748895

    APA Style (7th edition)

  • Horvat Davey, Christine. Gene Expression Profiling of Fatigue in Individuals with End Stage Renal Disease . 2019. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1564493520748895.

    MLA Style (8th edition)

  • Horvat Davey, Christine. "Gene Expression Profiling of Fatigue in Individuals with End Stage Renal Disease ." Doctoral dissertation, Case Western Reserve University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1564493520748895

    Chicago Manual of Style (17th edition)

case1564493520748895
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© 2019, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.