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MLindemann Thesis.pdf (1.52 MB)

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The Design and Development of a 3D Printed Hindlimb Stabilization Apparatus for the Measurement of Stimulation-Evoked Ankle Torque in the Rat

Lindemann, Madeline
http://orcid.org/0000-0002-0617-4525
http://rave.ohiolink.edu/etdc/view?acc_num=case1623426552144434

Abstract Details

2021, Master of Engineering, Case Western Reserve University, EMC - Mechanical Engineering.
Quantifying the chronic performance of a peripheral nerve electrode is critical to determine the long-term viability for the device in vivo. To develop a method of chronic evaluation, a non-invasive rodent hindlimb stabilization device was designed and tested to measure the resulting torque about the ankle joint due to sciatic nerve stimulation and isometric muscle contraction of the lower leg. With the increased accessibility of fused deposition modeling (FDM), eleven out of the fourteen custom-made components are fabricated using FDM printing to promote manufacturability and reduce cost. After benchtop calibration, an acute rodent study was conducted to assess apparatus measurement output and repeatability. The apparatus captured a maximum torque of 41.38 N-mm across rat subjects, which is consistent with published values in the literature. Apparatus inter-operator measurement variability calls for the development of a detailed protocol for apparatus use and repeatable implantation and evaluation of electrode stimulation-evoked ankle flexion.
Andrew Shoffstall (Committee Member)
Clare Rimnac (Committee Member)
Roger Quinn (Committee Chair)
79 p.
Biomechanics; Biomedical Engineering; Mechanical Engineering
electrode; noninvasive treatment; torque measurement; electrical stimulation; muscle; force measurement

Recommended Citations

Citations

  • Lindemann, M. (2021). The Design and Development of a 3D Printed Hindlimb Stabilization Apparatus for the Measurement of Stimulation-Evoked Ankle Torque in the Rat [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1623426552144434

    APA Style (7th edition)

  • Lindemann, Madeline. The Design and Development of a 3D Printed Hindlimb Stabilization Apparatus for the Measurement of Stimulation-Evoked Ankle Torque in the Rat. 2021. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1623426552144434.

    MLA Style (8th edition)

  • Lindemann, Madeline. "The Design and Development of a 3D Printed Hindlimb Stabilization Apparatus for the Measurement of Stimulation-Evoked Ankle Torque in the Rat." Master's thesis, Case Western Reserve University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623426552144434

    Chicago Manual of Style (17th edition)

case1623426552144434
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© 2021, some rights reserved.Creative Commons License The Design and Development of a 3D Printed Hindlimb Stabilization Apparatus for the Measurement of Stimulation-Evoked Ankle Torque in the Rat by Madeline Lindemann is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.