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FINAL ETD 1025455.pdf (4.13 MB)

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Development of Therapies for Treatment of Aggressive Cancers: Lessons from the Past and Current Perspectives

Arnold, Jennifer
http://orcid.org/0000-0002-2441-6348
http://rave.ohiolink.edu/etdc/view?acc_num=case1639083099160661

Abstract Details

2022, Master of Sciences, Case Western Reserve University, Pathology.
The development of effective chemotherapy regimens has had a tremendous positive impact on overall survival in patients with inoperable cancer. Despite these advances, developing new treatments to further improve survival and quality of life of patients remains a central goal of cancer research. Three independent projects highlighting different developmental approaches are presented here. First, a targeted therapy approach combining an antibody drug conjugate, ADCT-402, and the Bcl-2 inhibitor, Venetoclax, were tested in established leukemia and lymphoma lines. This combination proved to be synergistic through induction of apoptosis. Second, a series of compounds generated through a structurally based approach targeting ribonucleotide reductase (RNR) were shown to be effective against both a parental and gemcitabine resistant pancreatic cancer cell line. And third, a drug repositioning approach illustrated the potential of statins to reduce progression and metastasis in melanoma.
Pamela Wearsch (Advisor)
David Wald (Committee Member)
John Pink (Committee Chair)
91 p.
Cellular Biology

Recommended Citations

Citations

  • Arnold, J. (2022). Development of Therapies for Treatment of Aggressive Cancers: Lessons from the Past and Current Perspectives [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1639083099160661

    APA Style (7th edition)

  • Arnold, Jennifer. Development of Therapies for Treatment of Aggressive Cancers: Lessons from the Past and Current Perspectives. 2022. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1639083099160661.

    MLA Style (8th edition)

  • Arnold, Jennifer. "Development of Therapies for Treatment of Aggressive Cancers: Lessons from the Past and Current Perspectives." Master's thesis, Case Western Reserve University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=case1639083099160661

    Chicago Manual of Style (17th edition)

case1639083099160661
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.