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Radiomics Characterization of Perirectal Fat and Rectal Wall on MRI after Chemoradiation to Evaluate Pathologic Response and Treatment Outcomes in Rectal Cancer

Liu, Ziwei
http://rave.ohiolink.edu/etdc/view?acc_num=case1639147700132202

Abstract Details

2022, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Evaluating tumor regression and nodal metastasis in rectal cancers via MRI after standard-of-care chemoradiation therapy (CRT) remains highly challenging in clinical practice. Recent studies have shown that physiologic environments surrounding tumor regions may provide complementary information that is predictive of response to CRT and patient survival. In order to capture physiologic changes due to CRT within the rectal wall (primary location of tumor) and perirectal fat (region surrounding tumor), we evaluated the performance of radiomics characterization of these regions within the rectal environment on post-chemoradiation T2-weighted (T2w) MRI in predicting tumor regression and nodal response after CRT. A total of 83 rectal cancer patients for whom MRIs as well as pathologic tumor staging were available post-CRT were included in this study, from two different institutions. Region-wise radiomic features were extracted from expert annotated perirectal fat and rectal wall regions on MRI and a 2-stage feature selection was employed to identify the most relevant features from each of these locations. Combining radiomic features from across the fat and wall yielded significantly improved classifier performance for identifying tumor stage regression (AUC=0.86) as well as nodal metastasis (AUC = 0.7) when compared to the performance of these regions individually; a trend that generalized across discovery and hold-out validation. Top-ranked radiomic features were also found to be associated with pathologic complete response, surrogates of long-term survival, as well as revealed significant differences between age- and sex-specific subgroups.
Satish Viswanath (Committee Chair)
44 p.
Biomedical Engineering
radiomics; MRI; rectal cancer

Recommended Citations

Citations

  • Liu, Z. (2022). Radiomics Characterization of Perirectal Fat and Rectal Wall on MRI after Chemoradiation to Evaluate Pathologic Response and Treatment Outcomes in Rectal Cancer [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1639147700132202

    APA Style (7th edition)

  • Liu, Ziwei. Radiomics Characterization of Perirectal Fat and Rectal Wall on MRI after Chemoradiation to Evaluate Pathologic Response and Treatment Outcomes in Rectal Cancer. 2022. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1639147700132202.

    MLA Style (8th edition)

  • Liu, Ziwei. "Radiomics Characterization of Perirectal Fat and Rectal Wall on MRI after Chemoradiation to Evaluate Pathologic Response and Treatment Outcomes in Rectal Cancer." Master's thesis, Case Western Reserve University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=case1639147700132202

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.