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Thesis CWRU Erika Hutt.pdf (411.74 KB)

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RISK FACTORS OF VENTRICULAR ARRHYTHMIA AND CARDIOVASCULAR MORTALITY IN ADULTS WITH CARDIAC SARCOIDOSIS

Hutt, Erika
http://orcid.org/0000-0002-8271-6648
http://rave.ohiolink.edu/etdc/view?acc_num=case168060866334784

Abstract Details

2023, Master of Sciences, Case Western Reserve University, Clinical Research.
Identifying patients with cardiac sarcoidosis (CS) at increased risk of sudden cardiac death (SCD) is challenging. To better understand this, we evaluated a retrospective cohort of 273 adults with CS. The primary endpoint was a composite of ventricular arrhythmia (VA) and cardiovascular mortality. At median follow-up of 7.9 years, the rate of the primary endpoint was 35%. On Cox proportional hazard analysis, younger age, history of VA, lower left ventricular ejection fraction (LVEF) and any presence of scar by cardiac magnetic resonance (CMR) and/or positron emission tomography (PET) were found to be independent risk factors for the primary endpoint and for VA, whereas lower LVEF was an independent risk factor for cardiovascular mortality. The optimal cutoff LVEF for the primary composite endpoint was 45% in the entire cohort and 42% in subjects without a history of VA. In conclusion, history of VA, scar by either CMR or PET and a mild reduction in LVEF are strong risk factors for SCD in CS.
Wael Jaber (Committee Chair)
James Spilsbury (Advisor)
Paul Cremer (Committee Member)
Wilson Tang (Committee Member)
39 p.
Health Care; Medicine; Scientific Imaging
cardiac sarcoidosis, sudden cardiac death, ventricular arrhythmia, outcomes

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Citations

  • Hutt, E. (2023). RISK FACTORS OF VENTRICULAR ARRHYTHMIA AND CARDIOVASCULAR MORTALITY IN ADULTS WITH CARDIAC SARCOIDOSIS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case168060866334784

    APA Style (7th edition)

  • Hutt, Erika. RISK FACTORS OF VENTRICULAR ARRHYTHMIA AND CARDIOVASCULAR MORTALITY IN ADULTS WITH CARDIAC SARCOIDOSIS . 2023. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case168060866334784.

    MLA Style (8th edition)

  • Hutt, Erika. "RISK FACTORS OF VENTRICULAR ARRHYTHMIA AND CARDIOVASCULAR MORTALITY IN ADULTS WITH CARDIAC SARCOIDOSIS ." Master's thesis, Case Western Reserve University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=case168060866334784

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.