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Kerri Dissertation_Final_20E13A.pdf (6.21 MB)

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Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes

Smith, Kerri M
http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824

Abstract Details

2012, Doctor of Philosophy in Clinical-Bioanalytical Chemistry, Cleveland State University, College of Sciences and Health Professions.
Mass spectrometry is a valuable tool in the analysis of many types of compounds. From small molecules to large proteins, mass spectrometry can help to interrogate samples and give insights to the origins of disease as well as calculate an exact concentration. Bioanalytical method development is an integral component in the measurement of such compounds. To facilitate proper analytical investigation, the process of method development, analysis, and interpretation must be understood. This work describes the basis and procedure for bioanalytical method development and its detailed application to preclinical studies of the antineoplastic agent hexamethylene bisacetamide and measurement of illicit drugs of abuse benzylpiperazine and trifluoromethylphenyl piperazine using liquid chromatography tandem mass spectrometry. Additionally, procedures for analyzing protein-drug interactions and their implication in antibiotic resistance are discussed.
Yan Xu, Ph.D. (Committee Chair)
John Turner, Ph.D. (Committee Member)
Baochuan Guo, Ph.D. (Committee Member)
Yuping Wu, Ph.D. (Committee Member)
Xue-Long Sun, Ph.D. (Committee Member)
191 p.
Analytical Chemistry; Chemistry

Recommended Citations

Citations

  • Smith, K. M. (2012). Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824

    APA Style (7th edition)

  • Smith, Kerri. Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes . 2012. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824.

    MLA Style (8th edition)

  • Smith, Kerri. "Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes ." Doctoral dissertation, Cleveland State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824

    Chicago Manual of Style (17th edition)

csu1373987824
1,084
© 2011, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.