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THE INFLUENCE OF BDNF VAL66MET POLYMORPHISM ON COGNITION, DEPRESSION, QUALITY OF LIFE, AND MOTOR SYMPTOMS IN INDIVIDUALS WITH PARKINSON’S DISEASE AFTER DYNAMIC CYCLING

Harper, Sara Anne
http://rave.ohiolink.edu/etdc/view?acc_num=kent1478556216916353

Abstract Details

2016, PHD, Kent State University, College of Education, Health and Human Services / School of Health Sciences.
HARPER, SARA A., Ph.D., DECEMBER 2016 EDUCATION, HEALTH AND HUMAN SERVICES THE INFLUENCE OF VAL66MET POLYMORPHISM ON COGNITION, DEPRESSION, QUALITY OF LIFE, AND MOTOR SYMPTOMS IN INDIVIDUALS WITH PARKINSON’S DISEASE AFTER DYNAMIC CYCLING (203 pp.) Director of Dissertation: Angela L. Ridgel, Ph.D. BACKGROUND: Individuals with Parkinson’s disease (PD) tend to have high inter-individual variability in symptoms and in response to exercise. A genetic variation called brain derived neurotrophic factor (BDNF) Val66Met polymorphism may influence variability of attention and executive function domains, depression symptoms, quality of life, and motor symptoms after dynamic cycling. PURPOSE: The first aim was to determine if the prevalence of the Val66Met polymorphism influenced to incidences of attention and executive dysfunction, depression symptoms, decreased quality of life, and motor symptoms. The second aim was to determine if Val66Met polymorphism influenced changes in attention and executive function, depression symptoms, quality of life, and motor symptoms after dynamic cycling. METHODS: Fourteen participants (n=10, 6M/4F Val-allele group, n=4, 2M/2F Met-allele group, 64±9 years old), diagnosed with PD performed WebNeuro® testing, Montreal Cognition Assessment (MoCA), Beck Depression Inventory (BDI-II), EuroQOL questionnaire, Kinesia ONETM assessment, and Val66Met polymorphism genotyping. The intervention involved three, 40 minute dynamic cycling sessions. RESULTS: There was no influence of Val66Met polymorphism on the pre-intervention scores of attention, executive function, MoCA (cognition), depression symptoms, or motor symptoms. There were also no influences of Val66Met polymorphism on changes in attention, executive function, MoCA, depression symptoms or motor symptom after dynamic cycling. However, Val66Met polymorphism did have a main effect of group for quality of life questionnaire regardless of the cycling intervention. DISCUSSION: This intervention did not promote overall improvements. However, there were some interesting trends in the data and a larger sample size will likely result in more conclusive results.
Angela Ridgel (Committee Chair)
John McDaniel (Committee Member)
Mary Beth Spitznagel (Committee Member)
J. Derek Kingsley (Committee Member)
192 p.
Health Sciences

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Citations

  • Harper, S. A. (2016). THE INFLUENCE OF BDNF VAL66MET POLYMORPHISM ON COGNITION, DEPRESSION, QUALITY OF LIFE, AND MOTOR SYMPTOMS IN INDIVIDUALS WITH PARKINSON’S DISEASE AFTER DYNAMIC CYCLING [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1478556216916353

    APA Style (7th edition)

  • Harper, Sara. THE INFLUENCE OF BDNF VAL66MET POLYMORPHISM ON COGNITION, DEPRESSION, QUALITY OF LIFE, AND MOTOR SYMPTOMS IN INDIVIDUALS WITH PARKINSON’S DISEASE AFTER DYNAMIC CYCLING . 2016. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1478556216916353.

    MLA Style (8th edition)

  • Harper, Sara. "THE INFLUENCE OF BDNF VAL66MET POLYMORPHISM ON COGNITION, DEPRESSION, QUALITY OF LIFE, AND MOTOR SYMPTOMS IN INDIVIDUALS WITH PARKINSON’S DISEASE AFTER DYNAMIC CYCLING ." Doctoral dissertation, Kent State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1478556216916353

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Kent State University and OhioLINK.