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Suha Alqarni- MS Thesis.pdf (1.05 MB)

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Engineering Amphiphilic Platinum(IV) Prodrugs for Treating Drug Resistant Ovarian Cancer

Alqarni, Suha
http://orcid.org/0000-0001-7923-9257
http://rave.ohiolink.edu/etdc/view?acc_num=kent1668415630128673

Abstract Details

2022, MS, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
The platinum(IV) prodrug approach is a promising method to develop a replacement for classic platinum-based chemotherapy. The mitochondria-damaging Pt(IV) prodrugs have proven effective against drug-resistant ovarian cancer cells and cancer stem cells, which represent long-standing issues in classic platinum chemotherapy. In this work, we present a comprehensive study on engineering novel amphiphilic Pt(IV) prodrugs as mitochondria-damaging agents. The key findings in this study include: 1). Hydrophobicity of the head group of such prodrugs dictates their cell entry and cytotoxicity; 2). Amphiphilic Pt(IV) prodrugs exhibits superior therapeutic effects compared to cisplatin and overcomes drug resistance in ovarian cancer; 3). Amphiphilic Pt(IV) prodrugs trigger mitochondrial damage.
Yaorong Zheng (Advisor)
Hao Shen (Committee Member)
Songping Huang (Committee Member)
37 p.
Chemistry
ovarian cancer

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Citations

  • Alqarni, S. (2022). Engineering Amphiphilic Platinum(IV) Prodrugs for Treating Drug Resistant Ovarian Cancer [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1668415630128673

    APA Style (7th edition)

  • Alqarni, Suha. Engineering Amphiphilic Platinum(IV) Prodrugs for Treating Drug Resistant Ovarian Cancer. 2022. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1668415630128673.

    MLA Style (8th edition)

  • Alqarni, Suha. "Engineering Amphiphilic Platinum(IV) Prodrugs for Treating Drug Resistant Ovarian Cancer." Master's thesis, Kent State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=kent1668415630128673

    Chicago Manual of Style (17th edition)

kent1668415630128673
69
© 2022, some rights reserved.Creative Commons License Engineering Amphiphilic Platinum(IV) Prodrugs for Treating Drug Resistant Ovarian Cancer by Suha Alqarni is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Kent State University and OhioLINK.