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In Vitro Antimicrobial Activity of BTZ043 and PNU-100480 Against Mycobacterium ulcerans

Mutambuze, Jean Wilson
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399313048

Abstract Details

2014, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected emerging tropical disease that is characterized by necrosis of skin tissues. According to the World Health Organization, there are 5000-6000 cases of the disease reported annually from 33 countries. Although the majority of these cases occur in sub-Saharan Africa, Buruli ulcer has been reported in the Americas, Australia, and in Asia including China and Japan. Currently, three combinations of antimicrobials are used in addition to surgical procedures to treat the disease. These combinations include rifampicin and streptomycin, rifampicin and clarithromycin, and rifampicin and moxifloxacin. However, the effectiveness of the two last antimicrobial combinations has yet to be proven. M. ulcerans and Mycobacterium tuberculosis belong to the same genus. Because of this, antimicrobials that have shown to be effective or promising against M. tuberculosis are also potential candidates for treating M. ulcerans infection. In this study, using resazurin microtitre assays (REMA) we determined that the minimal inhibitory concentrations (MICs) of BTZ043 and PNU-100480 against M. ulcerans as 6.25 ng/ml and 62.5 ng/ml respectively. In addition, BTZ043 and PNU-100480 were also used in combination with various antimicrobials. Thus, the combination BTZ043 and PNU-100480, and the combinations of these two drugs with rifampicin and/or streptomycin systematically showed a synergistic effect with a decrease of MICs in each combination.
Jean Engohang-Ndong, PhD (Advisor)
Ruth Leslie, PhD (Committee Member)
Paul Sampson, PhD (Committee Member)
Douglas Kline, PhD (Committee Member)
51 p.
Biology; Biomedical Research; Medicine; Microbiology
mycobacterium ulcerans, burulu ulcer, BTZ043, PNU-100480

Recommended Citations

Citations

  • Mutambuze, J. W. (2014). In Vitro Antimicrobial Activity of BTZ043 and PNU-100480 Against Mycobacterium ulcerans [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399313048

    APA Style (7th edition)

  • Mutambuze, Jean. In Vitro Antimicrobial Activity of BTZ043 and PNU-100480 Against Mycobacterium ulcerans. 2014. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399313048.

    MLA Style (8th edition)

  • Mutambuze, Jean. "In Vitro Antimicrobial Activity of BTZ043 and PNU-100480 Against Mycobacterium ulcerans." Undergraduate thesis, Kent State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399313048

    Chicago Manual of Style (17th edition)

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© 2014, all rights reserved.
This open access ETD is published by Kent State University Honors College and OhioLINK.