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Studies toward the synthesis of photolabile HNO donors – an exploration of selectivity for HNO generation

Fejedelem, Zachary Alan
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1439560066

Abstract Details

2015, BS, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
HNO (nitroxyl) is a biologically relevant unstable small molecule which rapidly dimerizes in aqueous solution. Thus, there is a need for HNO donors that can quickly release HNO “on demand”. Our group has developed a first generation family of HNO donors which generate HNO rapidly through photolysis. However, some competition from a photoredox side reaction reduces the utility of these molecules. The goal of this thesis was to explore the impact of incorporating a methyl substituent on the rate and selectivity of HNO generation.
Paul Sampson, Ph.D. (Advisor)
Alexander Seed, Ph.D. (Advisor)
Ruth Leslie, Ph.D. (Committee Member)
Heather Caldwell, Ph.D. (Committee Member)
97 p.
Chemistry; Organic Chemistry
HNO; photolysis; nitroxyl; HNO donor; HNO donors

Recommended Citations

Citations

  • Fejedelem, Z. A. (2015). Studies toward the synthesis of photolabile HNO donors – an exploration of selectivity for HNO generation [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1439560066

    APA Style (7th edition)

  • Fejedelem, Zachary. Studies toward the synthesis of photolabile HNO donors – an exploration of selectivity for HNO generation. 2015. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1439560066.

    MLA Style (8th edition)

  • Fejedelem, Zachary. "Studies toward the synthesis of photolabile HNO donors – an exploration of selectivity for HNO generation." Undergraduate thesis, Kent State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1439560066

    Chicago Manual of Style (17th edition)

ksuhonors1439560066
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This open access ETD is published by Kent State University Honors College and OhioLINK.