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Blake Final Honors Thesis.pdf (701.51 KB)
ETD Abstract Container
Abstract Header
THE EFFECTS OF CITRAL ON CASPASE-3 ACTIVATION IN M624 AND HaCaT CELLS
Author Info
Szkoda, Blake E
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566418
Abstract Details
Year and Degree
2016, Bachelor of Science, Marietta College, Chemistry.
Abstract
Citral is a terpene compound found in the essential oils of lemon grass and other herbs. This study investigated the protective and cytotoxic effects of citral on HaCaT skin cells and M624 melanoma cells, respectively. Cells were cultured and exposed to varying concentrations of citral for three hours. Cell viability following treatment was analyzed using a clonogenic assay procedure. Results showed that citral has significant toxicity to M624 melanoma cells and little to no toxicity to HaCaT cells. The induction of apoptosis was measured using a caspase-3 colorimetric assay kit. This analysis showed that more caspase-3 protein was activated as the concentration of citral increased. Overall, the results of this study support the use of citral as an anticancer agent.
Committee
Suzanne George-Parsons, Dr. (Advisor)
Pages
32 p.
Subject Headings
Biochemistry
Keywords
M624 melanoma cells
;
HaCaT cells
;
Citral
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Citations
Szkoda, B. E. (2016).
THE EFFECTS OF CITRAL ON CASPASE-3 ACTIVATION IN M624 AND HaCaT CELLS
[Undergraduate thesis, Marietta College]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566418
APA Style (7th edition)
Szkoda, Blake.
THE EFFECTS OF CITRAL ON CASPASE-3 ACTIVATION IN M624 AND HaCaT CELLS.
2016. Marietta College, Undergraduate thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566418.
MLA Style (8th edition)
Szkoda, Blake. "THE EFFECTS OF CITRAL ON CASPASE-3 ACTIVATION IN M624 AND HaCaT CELLS." Undergraduate thesis, Marietta College, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566418
Chicago Manual of Style (17th edition)
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Document number:
marhonors1463566418
Download Count:
675
Copyright Info
© 2016, all rights reserved.
This open access ETD is published by Marietta College Honors Theses and OhioLINK.
Release 3.2.12