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Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC

Roach, Kylie A.
http://rave.ohiolink.edu/etdc/view?acc_num=mco1199283300

Abstract Details

2007, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Graduate Studies.
Francisella tularensisis a gram negative bacteria that is an intracellular pathogen that infects host macrophages. F. ularensissubspecies are able to survive and persist within macrophages and the bacterium employs various novel virulence mechanisms in order to persist. The gene iglC, intracellular growth locus C, was first identified to be involved in controlling intracellular growth. iglChas been shown to be important for manipulating the phagocytosis pathway, inducing host cell apoptosis and suppressing macrophage responses vital to clearing the infection. The work presented here focuses on delineating the mechanisms by which iglCallows F. novicidathe ability to grow and persist within macrophages. Intracellular growth, control of pro-inflammatory responses, effects of IFNã activation and the role of TLR4 responses were studied in order to better understand the virulence mechanisms of F. novicidaand the role iglCplays in this modulation of host and bacterial cell function.
R. Mark Wooten (Advisor)
92 p.
Francisella; iglC; Macrophage

Recommended Citations

Citations

  • Roach, K. A. (2007). Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1199283300

    APA Style (7th edition)

  • Roach, Kylie. Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC. 2007. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1199283300.

    MLA Style (8th edition)

  • Roach, Kylie. "Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC." Master's thesis, University of Toledo, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1199283300

    Chicago Manual of Style (17th edition)

mco1199283300
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© 2007, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.