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mco1279320879.pdf (2.01 MB)
ETD Abstract Container
Abstract Header
A Role for CEACAM2 in Insulin Homeostasis and Action
Author Info
Patel, Payal R.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=mco1279320879
Abstract Details
Year and Degree
2010, Doctor of Philosophy in Biomedical Sciences (Ph.D.), University of Toledo, College of Medicine.
Abstract
The carcinoembryonic antigen related cell adhesion molecule (CEACAM) family of proteins is involved in insulin signaling, lipogenesis, immunity, and tumor suppression. To identify a function for CEACAM2, we created a murine model without expression of the Ceacam2 gene. We report that the male Ceacam2 knockout mice are overall insulin sensitive. This occurs in light of hyperphagia and insulin resistance in skeletal muscle. Sensitivity is likely due to increased energy expenditure and to higher rates of insulin secretion. CEACAM2 localization to the ventromedial hypothalamus suggests a role for CEACAM2 in central regulation of energy balance and peripheral insulin action and secretion.
Committee
Sonia Najjar, PhD (Committee Chair)
Beata Lecka-Czernik, PhD (Committee Member)
Edith Mensah-Osman, MD PhD (Committee Member)
Sandrine Pierre, PhD (Committee Member)
Edwin Sanchez, Phd (Committee Member)
Pages
82 p.
Subject Headings
Biomedical Research
Keywords
ceacam
;
insulin sensitivity
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Citations
Patel, P. R. (2010).
A Role for CEACAM2 in Insulin Homeostasis and Action
[Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279320879
APA Style (7th edition)
Patel, Payal.
A Role for CEACAM2 in Insulin Homeostasis and Action.
2010. University of Toledo, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=mco1279320879.
MLA Style (8th edition)
Patel, Payal. "A Role for CEACAM2 in Insulin Homeostasis and Action." Doctoral dissertation, University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279320879
Chicago Manual of Style (17th edition)
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Document number:
mco1279320879
Download Count:
437
Copyright Info
© 2010, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.