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Image-Guided Adaptive Radiation Therapy: Retrospective Study and Assessment of Clinical Workflow

Hudson, Jason

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2013, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Medicine.
Patients undergoing intensity modulated radiation therapy are simulated prior to treatment using computed tomography. This simulation is used to develop a single treatment plan that will be used each day to deliver the prescribed dose of radiation. Daily volume changes of critical structures which may deviate from the volumes observed at the time of simulation, specifically in the case of prostate cancer patients, may alter the delivered dose to the planning target volume. The delivered dose to the prostate, seminal vesicles, rectum, bladder, and femoral heads have been re-calculated on daily cone-beam computed tomography setup images acquired prior to each treatment. The deviation from the planned dose to these critical structures has been evaluated on the basis of dose-volume statistics commonly used at this institution in the case of two prostate cancer patients, both on a daily basis and over the entire course of treatment in the way of accumulated dose. The average daily difference in the dose to ninety-five percent of the prostate from the planned dose was observed to be -1.40% and -0.42% for the primary and boost doses of radiation, respectively, in a prostate patient with standard margins. The average daily difference in the dose to ninety-five percent of the prostate was observed to be -1.13% over the course of treatment for a patient prescribed one dose of radiation with non-standard margins.
David Pearson, PhD (Committee Chair)
E. Ishmael Parsai, PhD (Committee Member)
Diana Shvydka, PhD (Committee Member)

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Citations

  • Hudson, J. (2013). Image-Guided Adaptive Radiation Therapy: Retrospective Study and Assessment of Clinical Workflow [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372268939

    APA Style (7th edition)

  • Hudson, Jason. Image-Guided Adaptive Radiation Therapy: Retrospective Study and Assessment of Clinical Workflow. 2013. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1372268939.

    MLA Style (8th edition)

  • Hudson, Jason. "Image-Guided Adaptive Radiation Therapy: Retrospective Study and Assessment of Clinical Workflow." Master's thesis, University of Toledo, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372268939

    Chicago Manual of Style (17th edition)