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The Evaluation of the Hindered Settling Behavior of the Never Dried Calcium Carbonate Suspension

Jain, Akshay
http://rave.ohiolink.edu/etdc/view?acc_num=mco1372858937

Abstract Details

2013, Master of Science in Pharmaceutical Science (MSP), University of Toledo, College of Pharmacy.
The aim of the study is to prepare and evaluate the hindered settling behavior of never dried calcium carbonate suspensions and the effect of various concentrations of Poloxamer 407® as a non-ionic surfactant. Never dried calcium carbonate suspensions have been prepared stoichiometrically by adding sodium bicarbonate to calcium chloride dihydrate. The various concentrations of Poloxamer 407® used for the hindered settling phenomenon were, 0.1%, 0.5%, 1% and 2% (w/v). Due to limitations, modifications of Stokes' law were used namely Steinour's equation, Richarson and Zaki's equation and Dollimore-McBride's equations. The determination of particle size was performed using a modified Stokes' equations along with laser diffraction. SEM was used for the morphological studies. The conclusion was made that, upon increasing the concentration of surfactant, flocculation increased with a further increase in particle size. Laser diffraction studies were in agreement with the hindered settling results and showed an increase in particle size with increasing poloxamer concentration. Kozeny and Carman permeability approach revealed that with increase in flocculation the permeability decreases. The reason concluded was that there was a reduction in the pore size. Zeta potential studies were crucial in explaining the DLVO theory and how it affected flocculation by a change in potential with a change in poloxamer concentration. Thermal analysis studies utilizing like Differential Scanning Calorimetry and Thermal Gravimetric Analysis were performed study the bound and unbound water content of the suspensions as well as the thermal decomposition with respect to weight against temperature. Powder X-Ray diffraction helped to establish the change in surface morphology of the particles as the peaks shift forward with increase in poloxamer concentration.
Kenneth S. Alexander, PhD (Committee Chair)
Sai H.S. Boddu, PhD (Committee Member)
Ming-Cheh Liu, PhD (Committee Member)
178 p.
Pharmacy Sciences

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Citations

  • Jain, A. (2013). The Evaluation of the Hindered Settling Behavior of the Never Dried Calcium Carbonate Suspension [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372858937

    APA Style (7th edition)

  • Jain, Akshay. The Evaluation of the Hindered Settling Behavior of the Never Dried Calcium Carbonate Suspension. 2013. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1372858937.

    MLA Style (8th edition)

  • Jain, Akshay. "The Evaluation of the Hindered Settling Behavior of the Never Dried Calcium Carbonate Suspension." Master's thesis, University of Toledo, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372858937

    Chicago Manual of Style (17th edition)

mco1372858937
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© 2013, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.