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Soohi's Thesis.pdf (2.27 MB)

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Development and Evaluation of a Nanomicellar Eye Drop Formulation of Dexamethasone for Posterior Uveitis

Patel, Soohi
http://rave.ohiolink.edu/etdc/view?acc_num=mco1404301496

Abstract Details

2014, Master of Science (MS), University of Toledo, Pharmaceutical Sciences (Industrial Pharmacy).
The overall objective of this study was to develop a clinically acceptable, mixed nanomicellar eye drop formulation of dexamethasone (DEXSOLV) for treating posterior uveitis. Nanomicelles were formulated using polyoxyl 40 stearate (P40S) and polysorbate 80 (P80), which are approved by US FDA for ocular use. The nanomicellar formulation was characterized for critical micellar concentration, solubility of dexamethasone, pH, particle size, zeta potential, morphology, differential scanning calorimetry, in vitro drug release, clarity, stability, filtration efficiency, and sterility. Ocular tolerance and the tissue drug distribution of DEXSOLV were assessed in rabbits following single and repeated topical administration. Nanomicellar formulation of dexamethasone (0.1%) was successfully developed and characterized with an optimized composition of P40S/P80 = 7/3 by weight. Transmission electron microscopy images revealed the spherical structure of micelles. DEXSOLV was found to be stable at 4C and 25C for up to 6 months. No irritation or redness was observed in the treated eyes as compared to the untreated control rabbit eyes. Therapeutic concentrations of dexamethasone were observed in the rabbit retina and choroid following single and repeated topical administration. In conclusion, the nanomicelles of P40S and P80 could efficiently solubilize dexamethasone in their cores, resulting in a stable aqueous eye drop formulation. Using this eye drop formulation, dexamethasone concentrations could be maintained well above the minimum effective concentrations following topical administration. The proposed topical therapy would enhance patient compliance and minimize the side-effects associated with intraocular implants and intravitreal injections in posterior uveitis therapy.
Sai Hanuman Sagar Boddu (Committee Chair)
Nanoscience; Nanotechnology; Pharmaceuticals; Pharmacy Sciences

Recommended Citations

Citations

  • Patel, S. (2014). Development and Evaluation of a Nanomicellar Eye Drop Formulation of Dexamethasone for Posterior Uveitis [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1404301496

    APA Style (7th edition)

  • Patel, Soohi. Development and Evaluation of a Nanomicellar Eye Drop Formulation of Dexamethasone for Posterior Uveitis. 2014. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1404301496.

    MLA Style (8th edition)

  • Patel, Soohi. "Development and Evaluation of a Nanomicellar Eye Drop Formulation of Dexamethasone for Posterior Uveitis." Master's thesis, University of Toledo, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1404301496

    Chicago Manual of Style (17th edition)

mco1404301496
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This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.