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CURTIS Thesis 2021.pdf (2.6 MB)

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Elucidating the Effects of Developmental Pyrethroid Pesticide Exposure in Mouse Brain Using a Multiomics Approach

Curtis, Melissa Ann
http://rave.ohiolink.edu/etdc/view?acc_num=mco1620320461694993

Abstract Details

2021, Master of Science in Biomedical Sciences (MSBS), University of Toledo, Biomedical Sciences (Bioinformatics and Proteomics/Genomics).
Autism Spectrum Disorder (ASD) is a cluster of incurable neurodevelopmental diseases with a prevalence of 1 in 54 people. Despite its very high incidence and a rise in prevalence each year, less than 10% of autism cases have an identifiable cause. This is in part because the causes are poorly understood and are thought to be both genetic and environmental. The recent CHARGE study (among others) has suggested that developmental exposure to pyrethroid pesticides, a common pesticide widely used due to its supposed safety, can lead to an increase in autism risk. To further evaluate the developmental effects of pyrethroid pesticide exposure, experiments were performed using two independent cohorts of mouse dams which were administered pyrethroid pesticide (or vehicle) during pregnancy and lactation. The offspring were raised to adulthood and euthanized for tissue collection. Split-sample transcriptomic, kinomic, and metabolomic analyses were performed on the brain tissue collected, to provide a comprehensive understanding of the multi-modal biophenotype induced by pyrethroid exposure. Results for each of the analyses are discussed in the context of contribution of developmental pesticide exposure to autism risk.
James Burkett (Committee Chair)
105 p.
Bioinformatics; Neurosciences
Bioinformatics; Transcriptomic; Kinomic; Metabolomic; Autism

Recommended Citations

Citations

  • Curtis, M. A. (2021). Elucidating the Effects of Developmental Pyrethroid Pesticide Exposure in Mouse Brain Using a Multiomics Approach [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1620320461694993

    APA Style (7th edition)

  • Curtis, Melissa. Elucidating the Effects of Developmental Pyrethroid Pesticide Exposure in Mouse Brain Using a Multiomics Approach. 2021. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1620320461694993.

    MLA Style (8th edition)

  • Curtis, Melissa. "Elucidating the Effects of Developmental Pyrethroid Pesticide Exposure in Mouse Brain Using a Multiomics Approach." Master's thesis, University of Toledo, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=mco1620320461694993

    Chicago Manual of Style (17th edition)

mco1620320461694993
91
© 2021, some rights reserved.Creative Commons License Elucidating the Effects of Developmental Pyrethroid Pesticide Exposure in Mouse Brain Using a Multiomics Approach by Melissa Ann Curtis is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.