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Byrne Thesis Final.pdf (1.61 MB)

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Evaluating Plan Quality for Multi-Target Brain Radiosurgery: Single Iso Multi-Target vs Single Iso Single Target Planning

Byrne, Justin Joseph
http://rave.ohiolink.edu/etdc/view?acc_num=mco1651858933739259

Abstract Details

2022, Master of Science in Biomedical Sciences (MSBS), University of Toledo, Biomedical Sciences (Medical Physics: Radiation Oncology).
Purpose: The purpose of this study is to evaluate plan quality for single isocenter single target (SIST) vs. single isocenter multiple targets (SIMT) methods with regards to V12(cc), V8(cc) as well as Paddick conformity (PCI), RTOG conformity (RTOG_CI) and Paddick gradient index (PGI). Methods: 21 anonymized patient cranial CT scans were used to create treatment plans in RayStation (v10). The number of targets varied between 4-12 per patient. They were different sizes and distances apart from each other. All targets received the same dose level (24 Gy in 3 fractions) in both plan types. SIMT plans used an isocenter at the midpoint of all targets, with five arcs evenly between 270 and 90-degree couch angles. SIST plans were also made for all targets individually, using five, non-coplanar arcs, designed to minimize exposure to other targets. The SIMT dose distribution was compared to the composite dose of SIST plans by calculating the PCI, RTOG_CI, PGI, V12, and V8 SPSS (v27) was used for two sample T-Test. Results: A significant difference was observed between the two treatment methods for PCI, RTOG_CI. SIMT plans yield better PCI and RTOG_CI compared to SIST, while PGI & V8 were lower for the SIST technique. No significant difference was observed between the two methods for V12. As the target volumes increased the Paddick and RTOG conformities improved for both techniques. The SIMT treatment plans see much improvement over the SIST as the distance between targets decrease and also as the number of targets increase. The mean V12, V8, and GI, however, were better for SIST plans. Conclusion: Quality indices, together with time considerations, reveal an advantage in single isocenter multi-target planning when there are 3-5 targets. If local exposure to critical structures is of concern, especially as the number of targets increases, then the use of multiple isocenters should be considered.
E. Ishmael Parsai, Ph.D. (Advisor)
David Pearson, Ph.D. (Committee Member)
Nicholas Sperling, Ph.D. (Committee Member)
54 p.
Oncology; Physics; Radiation
VMAT; SIST; SIMT; Radiosurgery; Multitarget; Treatment Planning

Recommended Citations

Citations

  • Byrne, J. J. (2022). Evaluating Plan Quality for Multi-Target Brain Radiosurgery: Single Iso Multi-Target vs Single Iso Single Target Planning [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1651858933739259

    APA Style (7th edition)

  • Byrne, Justin. Evaluating Plan Quality for Multi-Target Brain Radiosurgery: Single Iso Multi-Target vs Single Iso Single Target Planning. 2022. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1651858933739259.

    MLA Style (8th edition)

  • Byrne, Justin. "Evaluating Plan Quality for Multi-Target Brain Radiosurgery: Single Iso Multi-Target vs Single Iso Single Target Planning." Master's thesis, University of Toledo, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=mco1651858933739259

    Chicago Manual of Style (17th edition)

mco1651858933739259
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This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.