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THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss)

Smith, Carrie Anne
http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356

Abstract Details

2003, Master of Science, Miami University, Zoology.
The objective of this research was to develop, evaluate and apply a physiologically based toxicokinetic model for the uptake of waterborne fluoranthene in rainbow trout. The model was parameterized and solved to predict the time course of fluoranthene in the liver, kidney, fat, poorly and richly perfused tissues, gonads, and brain of trout. Tissue concentrations observed after exposing trout to fluoranthene were compared with predicted tissue concentrations to evaluate the model. The model poorly characterized fluoranthene distribution during the initial uptake phase and accurately predicted uptake at later times. A suspected deviation from one of the model’s primary assumptions (flow-limited exchange) explained the discrepancies between observed and predicted fluoranthene concentrations at early times. The model was applied to predict fluoranthene uptake across the biological temperature range of trout and throughout the reproductive cycle of female trout. In general, uptake increased with temperature and decreased in the ovaries as spawning approached.
James Oris (Advisor)
83 p.
Environmental Sciences
Toxicokinetic; Polycyclic Aromatic Hydrocarbon; Rainbow Trout; Model; Physiologically-based

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Citations

  • Smith, C. A. (2003). THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss) [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356

    APA Style (7th edition)

  • Smith, Carrie. THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss). 2003. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356.

    MLA Style (8th edition)

  • Smith, Carrie. "THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss)." Master's thesis, Miami University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356

    Chicago Manual of Style (17th edition)

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© 2003, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.