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DORSAL HIPPOCAMPUS, VENTRAL HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX IN TRACE AND CONTEXTUAL FEAR MEMORY EXPRESSION: IMPORTANCE OF THE LESION TO TEST INTERVAL

Beeman, Christopher L.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1343314656

Abstract Details

2012, Master of Arts, Miami University, Psychology.
Previous work has shown that lesions of the dorsal hippocampus (DH) at recent but not remote times following training, produce deficits in memory expression. The opposite pattern was observed with lesions of the medial prefrontal cortex (mPFC). In Experiment 1, excitotoxic lesions of the DH, ventral hippocampus (VH) or mPFC were made at 1 or 30 days following trace fear conditioning. Results showed a temporally-graded deficit in the DH and VH and mPFC lesioned animals in trace fear recall, but not simultaneously-learned contextual fear. In Experiment 2, the same lesions were made one day following training and testing was delayed for thirty days. This allowed for recovery of trace fear memory, but not contextual fear. These results suggest that systems-consolidation of trace fear memory occurs during the course of 30 days, is similar in both VH and DH, and is not disrupted in animals without intact HPC or mPFC.
Jennifer Quinn, PhD (Committee Chair)
Stephen Berry, PhD (Committee Member)
Dragana Claflin, PhD (Committee Member)
28 p.
Behavioral Sciences; Neurobiology; Neurosciences; Psychology; Zoology
Hippocampus; Medial Prefrontal Cortex; Memory; Learning; Fear Conditioning; Rodent; Systems Consolidation;

Recommended Citations

Citations

  • Beeman, C. L. (2012). DORSAL HIPPOCAMPUS, VENTRAL HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX IN TRACE AND CONTEXTUAL FEAR MEMORY EXPRESSION: IMPORTANCE OF THE LESION TO TEST INTERVAL [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1343314656

    APA Style (7th edition)

  • Beeman, Christopher. DORSAL HIPPOCAMPUS, VENTRAL HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX IN TRACE AND CONTEXTUAL FEAR MEMORY EXPRESSION: IMPORTANCE OF THE LESION TO TEST INTERVAL. 2012. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1343314656.

    MLA Style (8th edition)

  • Beeman, Christopher. "DORSAL HIPPOCAMPUS, VENTRAL HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX IN TRACE AND CONTEXTUAL FEAR MEMORY EXPRESSION: IMPORTANCE OF THE LESION TO TEST INTERVAL." Master's thesis, Miami University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1343314656

    Chicago Manual of Style (17th edition)

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© 2012, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.