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Plasticity in the intermediolateral cell column of the spinal cord following injury to sympathetic postganglionic axons

Gannon, Sean Michael
http://rave.ohiolink.edu/etdc/view?acc_num=miami1407112137

Abstract Details

2014, Master of Science, Miami University, Zoology.
The effects of transection of sympathetic postganglionic axons on uninjured, preganglionic neurons arising from the spinal cord were examined in this study. Protein levels of choline acetyltransferase (ChAT) were decreased in the superior cervical ganglion after axotomy at short term and long term survival time points, suggesting a response by the uninjured ChAT preganglionic axons. Yet no parallel changes were observed in ChAT protein expression or in the morphology of preganglionic somata in the spinal cord intermediolateral cell column. However, at long term survival time points following the axotomy, a decrease in the number of synaptic boutons making contact with the somata of IML neurons was observed, suggesting that injury to peripheral axons can result in chronic retrograde transsynaptic changes and providing evidence that the effects of peripheral injury can cascade into the central nervous system.
Lori Isaacson, PhD (Advisor)
Kathleen Killian, PhD (Committee Member)
Jennifer Quinn, PhD (Committee Member)
53 p.
Biology; Cellular Biology; Neurobiology; Neurosciences
intermediolateral cell column; IML; transneuronal effects of injury; superior cervical ganglion; SCG; sympathetic; plasticity; paraventricular nucleus; PVN; choline acetyltransferase; ChAT; transsynaptic; corticotropin-releasing factor; CRF; spinal cord

Recommended Citations

Citations

  • Gannon, S. M. (2014). Plasticity in the intermediolateral cell column of the spinal cord following injury to sympathetic postganglionic axons [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1407112137

    APA Style (7th edition)

  • Gannon, Sean. Plasticity in the intermediolateral cell column of the spinal cord following injury to sympathetic postganglionic axons . 2014. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1407112137.

    MLA Style (8th edition)

  • Gannon, Sean. "Plasticity in the intermediolateral cell column of the spinal cord following injury to sympathetic postganglionic axons ." Master's thesis, Miami University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1407112137

    Chicago Manual of Style (17th edition)

miami1407112137
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© 2014, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.
Release 3.2.12