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Dissertation Final.pdf (6.87 MB)

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Optimization of Stem Cell Therapies for Coronary Collateral Growth in Cardiovascular Disease

Logan, Suzanna J
http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1401096082

Abstract Details

2014, Doctor of Philosophy, Northeast Ohio Medical University, Integrated Pharmaceutical Medicine.
Ischemic heart disease is a leading cause of death around the world. Coronary collateral growth occurs as a natural, adaptive response to myocardial ischemia, and provides an alternate path for blood to flow to the area at risk. Many patients with ischemic heart disease demonstrate insufficient collateral growth and thus remain at high risk for myocardial infarction and heart failure. Stem cell therapies may have the potential to augment collateral growth in these patients. However, clinical trials using stem cells to increase myocardial blood flow have shown minimal benefit. Perhaps the harsh, oxidative environment into which stem cells are administered may contribute to excessive cell death prior to achieving a therapeutic effect. These experiments are based upon the overall hypothesis that stem cells conditioned to withstand oxidative stress in culture will produce greater increases in coronary collateral growth upon delivery in vivo.
William Chilian, PhD (Advisor)
Marc Penn, MD/PhD (Committee Member)
Angelo Delucia, PhD (Committee Member)
Liya Yin, MD/PhD (Committee Member)
Richard Carroll, PhD (Committee Member)
211 p.
Cellular Biology; Health; Medicine
Arteriogenesis, stem cells, ischemic heart disease, coronary collateral growth, oxidative stress, thiazolidinediones

Recommended Citations

Citations

  • Logan, S. J. (2014). Optimization of Stem Cell Therapies for Coronary Collateral Growth in Cardiovascular Disease [Doctoral dissertation, Northeast Ohio Medical University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1401096082

    APA Style (7th edition)

  • Logan, Suzanna. Optimization of Stem Cell Therapies for Coronary Collateral Growth in Cardiovascular Disease. 2014. Northeast Ohio Medical University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1401096082.

    MLA Style (8th edition)

  • Logan, Suzanna. "Optimization of Stem Cell Therapies for Coronary Collateral Growth in Cardiovascular Disease." Doctoral dissertation, Northeast Ohio Medical University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1401096082

    Chicago Manual of Style (17th edition)

ne2mh1401096082
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© 2014, all rights reserved.
This open access ETD is published by NEOMED Integrated Pharmaceutical Medicine and OhioLINK.