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The Effects of Dietary ß-Hydroxy-ß-Methylbutyrate + ß-Alanine and Physical Activity on Muscle Morphology and Function in Aged Rats

Acksel, Cara L.
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1417463567

Abstract Details

2014, Master of Science (MS), Ohio University, Food and Nutrition Sciences (Health Sciences and Professions).
Loss of muscle mass and strength is a major health concern for the aging population. Both physical activity and dietary amino acid supplementation are suggested to play a role in increasing muscle mass, though little is known regarding the effect of these interventions on strength and muscle quality. In the present study, forty 22-month Sprague-Dawley rats were placed on a supplemental diet, running regimen, both, or neither (control). Running habits were tracked and analyzed. The medial gastrocnemius was tested to determine muscle mass, force, quality, fatigability, and fiber type. A significant difference was seen in MHC I fiber concentration, MuRF-1 activity, and absolute change in running pace between some groups. The results suggest that that physical activity might have played a larger role then HMB in MHC composition, MuRF-1 activity, muscle quality, and running pace.
Robert Brannan, PhD (Committee Chair)
David Russ, PT, PhD (Committee Member)
Anne Loucks, PhD (Committee Member)
105 p.
Aging; Nutrition; Physiology
muscle quality; aging; HMB; physical activity

Recommended Citations

Citations

  • Acksel, C. L. (2014). The Effects of Dietary ß-Hydroxy-ß-Methylbutyrate + ß-Alanine and Physical Activity on Muscle Morphology and Function in Aged Rats [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1417463567

    APA Style (7th edition)

  • Acksel, Cara. The Effects of Dietary ß-Hydroxy-ß-Methylbutyrate + ß-Alanine and Physical Activity on Muscle Morphology and Function in Aged Rats. 2014. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1417463567.

    MLA Style (8th edition)

  • Acksel, Cara. "The Effects of Dietary ß-Hydroxy-ß-Methylbutyrate + ß-Alanine and Physical Activity on Muscle Morphology and Function in Aged Rats." Master's thesis, Ohio University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1417463567

    Chicago Manual of Style (17th edition)

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© 2014, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.