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Novel Isosteviol Derivatives as Potential Anticancer Agents

Laha, Rumita
http://orcid.org/0000-0002-0472-8096
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396

Abstract Details

2018, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Diterpenes are natural products that provide an interesting lead for anticancer drug discovery. For our studies the readily available diterpene Steviol was used. Our research group has an interest in making diterpene analogs using stevioside as starting material and tests them for cytotoxic activity against various cancer cell lines. The tetracyclic-diterpenoid isosteviol (ent-16-ketobeyeran-19-oic acid) was obtained in large quantity from the acid hydrolysis of steviol glycosides. We used isosteviol to prepare novel structural derivatives in parallel fashion. These analogs were assayed in a number of cancer cell lines in order to identify new anticancer agents. Our prime goal in this dissertation is to show how natural product with pre-existing chiral centers can be used for the synthesis of unique small molecule libraries. We also discussed how these libraries can be further optimized for the discovery of new therapeutics.
Stephen Bergmeier (Advisor)
Jennifer Hines (Committee Member)
Michael Held (Committee Member)
Douglas Goetz (Committee Member)
210 p.
Organic Chemistry
Isosteviol

Recommended Citations

Citations

  • Laha, R. (2018). Novel Isosteviol Derivatives as Potential Anticancer Agents [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396

    APA Style (7th edition)

  • Laha, Rumita. Novel Isosteviol Derivatives as Potential Anticancer Agents. 2018. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396.

    MLA Style (8th edition)

  • Laha, Rumita. "Novel Isosteviol Derivatives as Potential Anticancer Agents." Doctoral dissertation, Ohio University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396

    Chicago Manual of Style (17th edition)

ohiou1512733339403396
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