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The Acute-Phase Response and Cancer Risk

Sivak-Sears, Niccole R.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439

Abstract Details

2003, Doctor of Philosophy, Ohio State University, Public Health.
This dissertation contains three investigations that evaluate hypotheses concerning associations between the acute phase response (APR) and cancer. The APR is a coordinated sequence of systemic and metabolic changes occurring in response to acute and chronic stimuli, including pathogens, injury, and cancer. The goal of the first investigation (chapter 2) was to determine whether the previously observed associations between serum antioxidant and ferritin concentrations and cancer risk are actually attributable to the effect of the APR (caused by the pre-existing cancer) on serum antioxidant and ferritin levels. Individuals with 1) a prior cancer diagnosis, 2) previous heart attack, and 3) neither a history of cancer nor heart attack, had similar serum antioxidant levels so the question of whether the APR is responsible for the decrease of serum antioxidants observed in cancer patients could not be addressed. However, individuals in the cancer and heart attack groups with the highest APRs showed higher serum ferritin levels and lower serum iron levels than did individuals with the highest APRs in the group without these diseases. These findings suggest that the APR is responsible for differences in serum ferritin and serum iron levels among the three groups. The second investigation (chapter 3) evaluated the association between the chronic inflammatory condition, periodontal disease, and risk of lung cancer. We found no association between periodontal disease and lung cancer risk in women. Among men, a statistically significant trend of an increase in lung cancer risk with increasing periodontal disease severity was observed (p=0.0008), however this risk was restricted to smoking males; nonsmoking males showed no association between periodontal disease and lung cancer risk. These findings indicate either a modifying effect of smoking on gum disease or residual confounding by smoking. The third investigation (chapter 4) evaluated the association between use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) and adult glioblastoma multiforme risk. Self-reported glioblastoma multiforme cases were less likely than controls to report use of at least 600 pills of all types of NSAIDs combined during the ten year pre-diagnostic period. Findings were consistent for aspirin, ibuprofen, and naproxen/other NSAIDs, as well as for acetaminophen.
Judith Schwartzbaum (Advisor)
190 p.
Acute-Phase Response; Inflammatory Response; Cancer Risk; Lung Cancer; Serum Antioxidants; Serum Ferritin; Periodontal Disease; NSAIDs; Glioblastoma Multiforme

Recommended Citations

Citations

  • Sivak-Sears, N. R. (2003). The Acute-Phase Response and Cancer Risk [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439

    APA Style (7th edition)

  • Sivak-Sears, Niccole. The Acute-Phase Response and Cancer Risk. 2003. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439.

    MLA Style (8th edition)

  • Sivak-Sears, Niccole. "The Acute-Phase Response and Cancer Risk." Doctoral dissertation, Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1053636439

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.