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Optimization of cancer chemotherapy: local delivery of paclitaxel and pharmacokinetics of suramin

Hu, Xiao
http://rave.ohiolink.edu/etdc/view?acc_num=osu1101309924

Abstract Details

2004, Doctor of Philosophy, Ohio State University, Pharmacy.
Cancer remains a major public health problem in the United States and in other developed countries. Our knowledge in tumor biology has not been accordingly translated into new substantially better anticancer drugs. The yield of new effective anticancer is low. Drug delivery and dosing regimen compose two major limitations for anticancer drug efficacy. The overall objective of the work presented in this dissertation was to optimize cancer chemotherapy. Chapters 2 and 3 contribute scientifically to the field of regional cancer chemotherapy, with a specific focus on prostate cancer. Chapters 4, 5 and 6 contribute to the different aspects of pharmacokinetics, including interspecies scaling, population pharmacokinetics, and tissue distribution. The reader will find that the work presented in this thesis spans many areas within the pharmaceutical sciences. The major conclusions and contributions of the research in this dissertation are as follows: (a) the establishment of paclitaxel loaded biodegradable implants that have desired in vitro release profile; (b) the efficacy of the drug delivery system was tested in PC-3 tumor bearing mice. The drug loaded cylinders inhibited tumor growth, while the system exposure is negligible; (c) establishment of allometric relationship across four species for low-dose suramin; (d) development and validation of empirical equations for suramin dosing regimen in dog cancer patients; (5) study of tissue distribution of low-dose suramin and development of local PKPB model. The research in this dissertation spanned multiple disciplines and covered many areas of the pharmaceutical sciences, from drug delivery to pharmacokinetics, from in vitro to in vivo. Hopefully, this work can give readers some ideas to improve the yield of new drugs.
M. Guillaume Wientjes (Advisor)
181 p.
Health Sciences, Pharmacy
SURAMIN; PACLITAXEL; prostate; tumor; PHARMACOKINETICS; CANCER

Recommended Citations

Citations

  • Hu, X. (2004). Optimization of cancer chemotherapy: local delivery of paclitaxel and pharmacokinetics of suramin [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1101309924

    APA Style (7th edition)

  • Hu, Xiao. Optimization of cancer chemotherapy: local delivery of paclitaxel and pharmacokinetics of suramin. 2004. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1101309924.

    MLA Style (8th edition)

  • Hu, Xiao. "Optimization of cancer chemotherapy: local delivery of paclitaxel and pharmacokinetics of suramin." Doctoral dissertation, Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1101309924

    Chicago Manual of Style (17th edition)

osu1101309924
2,404
© 2004, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.