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A role for cytoplasmic PML in the cellular antiviral response

McNally, Beth Anne
http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007

Abstract Details

2005, Doctor of Philosophy, Ohio State University, Pathology.
In the co-evolution of cellular host and virus, both cellular and viral proteins and their protein functions have adapted to equip each player for a battle of survival. In pages to follow we characterize a novel cellular antiviral molecule called PML Ib, and shed some light on the delicate interplay that exists between this cellular protein and the HSV-1 Immediate Early Infected Cell Protein 0 (ICP0). Herein our studies reveal a surprising role for a unique cytoplasmic isoform of PML in the cellular defense of HSV-1. Our data supports a model by which PML Ib influences the proteosomal degradation of ICP0 and renders wild type infections similar to that of ICP0 null mutants, We also show that the 3’ untranslated (UTR) region of PML Ib is subject to nucleotidic editing implicating a means by which this particular PML isoform may be regulated and manipulated. Lastly, we uncover a mechanism by which a virus other than HSV-1 may evade the antiviral shield set up by PML Ib implicating, perhaps, a more expansive role for this protein as an induced effector molecule of the innate immune response.
Pan Zheng (Advisor)
160 p.
cytoplasmic PML; HSV-1; ICP0; RNA editing

Recommended Citations

Citations

  • McNally, B. A. (2005). A role for cytoplasmic PML in the cellular antiviral response [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007

    APA Style (7th edition)

  • McNally, Beth. A role for cytoplasmic PML in the cellular antiviral response. 2005. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007.

    MLA Style (8th edition)

  • McNally, Beth. "A role for cytoplasmic PML in the cellular antiviral response." Doctoral dissertation, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1133377007

    Chicago Manual of Style (17th edition)

osu1133377007
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© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.
Release 3.2.12