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Saponins: bioactivity and potential impact on intestinal health

Carlson, Emily M.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1244477535

Abstract Details

2009, Master of Science, Ohio State University, OSU Nutrition.
Saponins, a structurally diverse family of secondary plant metabolites, possess anti-carcinogenic, hypolipemic, hypocholesterolemic, and immune-enhancing activities. We have initiated studies comparing the effects of saponins extracted from several sources including soy, tomato, chickpea, fenugreek, and a commercial mixture of phytosterols (positive control) on GI metabolism and transport of cholesterol and on interactions between gut microbes and intestinal epithelial cells. During simulated gastric and small intestinal digestion, saponins (90 µM) from tomato and mixed phytosterols significantly inhibited micellarization of cholesterol (14 µM) from a food matrix. Saponins from tomato reduced the incorporation of cholesterol into synthetic micelles by 60%, whereas other test compounds (saponins from soya, chickpea and fenugreek and phytosterols) were without effect. Saponins from soy and tomato, as well as phytosterols, also significantly impaired the micellar transfer of cholesterol into differentiated cultures of human intestinal Caco-2 cells. Additionally, soyasaponins decreased adherence and invasion of Caco cells by Salmonella enterica serovar Typhimurium. These preliminary observations suggest that saponins in food crops important to Ohio’s economy may contribute to cardiovascular and gastrointestinal health.
Mark Faill, Dr. (Advisor)
Joshua Bomser, Dr. (Committee Member)
Yael Vodovotz, Dr. (Committee Member)
62 p.
Health; Nutrition
soy; saponins; intestinal health; Salmonella; bacteria; gut health; hypocholesterolemia; phystosterols

Recommended Citations

Citations

  • Carlson, E. M. (2009). Saponins: bioactivity and potential impact on intestinal health [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1244477535

    APA Style (7th edition)

  • Carlson, Emily. Saponins: bioactivity and potential impact on intestinal health. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1244477535.

    MLA Style (8th edition)

  • Carlson, Emily. "Saponins: bioactivity and potential impact on intestinal health." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1244477535

    Chicago Manual of Style (17th edition)

osu1244477535
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© 2009, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.