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Biomarkers as Predictors of Ankylosis

Beck, Stephen
http://rave.ohiolink.edu/etdc/view?acc_num=osu1274908825

Abstract Details

2010, Master of Science, Ohio State University, Dentistry.
Objectives: The purpose of this study was to determine if biomarkers were significantly different between ankylosed and normally healed avulsed permanent teeth. Methods: Patients who presented to Nationwide Children's Hospital with an avulsed permanent incisor were enrolled in the study. Socket irrigant was collected prior to replantation of the tooth. Irrigant was saved in a deep freeze for further analysis. The patient’s pulp tissue was also harvested and stored for analysis at the pulp extirpation visit 7-21 days following the initial injury. Follow up visits were performed in accordance with International Association of Dental Traumatology guidelines. After all follow up visits patients were placed in one of two groups, ankylosed and normally healed. Using a 27-plex qualitative bio-assay array, multiple biomarkers were assessed at a single time to determine if any difference existed between either ankylosis or normally healed teeth in socket and pulp samples. Results: 12 patients with 16 teeth were enrolled in the study after all exclusion criteria. Four (25%) healed normally without any sign of replacement resorption and 12 (75%) ankylosed with either percussion or radiographic changes. Pro-inflammatory biomarkers, anti-inflammatory biomarkers, and growth factors did not demonstrate a statistically significant difference between groups in either socket or pulp samples. Conclusion: Further studies with a greater number of samples need to be undertaken to determine if any difference in biomarkers exist between ankylosed and normally healed teeth.
Dennis McTigue (Advisor)
Purnima Kumar (Committee Member)
Kumar Subramanian (Committee Member)
Ashok Kumar (Committee Member)
53 p.
Dental Care
Biomarkers; ankylosis; avulsion

Recommended Citations

Citations

  • Beck, S. (2010). Biomarkers as Predictors of Ankylosis [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274908825

    APA Style (7th edition)

  • Beck, Stephen. Biomarkers as Predictors of Ankylosis. 2010. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1274908825.

    MLA Style (8th edition)

  • Beck, Stephen. "Biomarkers as Predictors of Ankylosis." Master's thesis, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274908825

    Chicago Manual of Style (17th edition)

osu1274908825
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This open access ETD is published by The Ohio State University and OhioLINK.