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Unique Applications of Nanomaterials in Separation Science

Clark, Jonathan Edward
http://rave.ohiolink.edu/etdc/view?acc_num=osu1282335513

Abstract Details

2010, Doctor of Philosophy, Ohio State University, Chemistry.
Separation efficiency is inversely related to stationary phase diameter. Improvements in stationary phase manufacturing have led to micron-sized particles for packing. If packing materials could be decreased down to the nanometer scale, the band dispersion would theoretically be lowered by 6 orders of magnitude. However, the quest towards the use of nanomaterials in chromatography has encountered serious challenges such as extremely high back pressures and problems associated with frits. Ideal chromatographic methods to examine the performance of nano-stationary phases would be free of complicated packing methods. Work described in this dissertation illustrates two such techniques: ultra-thin layer chromatography (UTLC) and electrokinetic chromatography (EKC). Electrospinning is a simple and inexpensive method to create nanomaterials of different morphology (i.e. fibers, ribbons, beads) and was found to be an ideal way to fabricate TLC devices with nanoscale stationary phases. Polymer stationary phases such as polyacrylonitrile (PAN) as well as glassy carbon nanofibers demonstrate superior chromatographic properties in the separation of laser dyes, steroidal compounds and fluorescently labeled essential amino acids. Electrokinetic chromatography (EKC) has also been shown to be a nano-compatible chromatographic method. EKC takes advantage of a mobile, pseudo-stationary phase (PSP) plug rather than a packed or immobilized phase. Studies of ordered carbon nanomaterials and their retention characteristics are described using electrokinetic chromatography. Small organic molecules and their acids were used as initial analytes to elucidate the selectivity of the edge-plane carbon nanorods and compared to results obtained using amorphous carbon nanorods. A separation of 4 beta blocker pharmaceuticals were also separated using edge-plane carbon PSP. The electrical properties of unique carbon nanomaterials studied in this dissertation are also examined in Chapter 5 to aid in the understanding of these materials in an electrically driven method such as EKC.
Susan Olesik, PhD (Advisor)
Terry Gustafson, PhD (Committee Member)
Prabir Dutta, PhD (Committee Member)
298 p.
Chemistry

Recommended Citations

Citations

  • Clark, J. E. (2010). Unique Applications of Nanomaterials in Separation Science [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1282335513

    APA Style (7th edition)

  • Clark, Jonathan. Unique Applications of Nanomaterials in Separation Science. 2010. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1282335513.

    MLA Style (8th edition)

  • Clark, Jonathan. "Unique Applications of Nanomaterials in Separation Science." Doctoral dissertation, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1282335513

    Chicago Manual of Style (17th edition)

osu1282335513
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© 2010, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.