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Effects of Neural Sympathetic Nerve Activity and Endothelial Function on Ventriculovascular Coupling Efficiency in Resistance and Endurance Trained Athletes

Smith, Michael M.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1335984673

Abstract Details

2012, Doctor of Philosophy, Ohio State University, EDU Physical Activity and Educational Services.
Increased arterial stiffness is associated with an impairment of ventricular-vascular coupling efficiency and increased risk of cardiovascular mortality. Recent reports have indicated a possible role of resistance exercise training performed absent an aerobic exercise program for increasing arterial stiffness. Therefore, the aims of this study were to compare augmentation index (AIx) and left ventricular wasted pressure energy (LVEW) as markers of arterial stiffness and ventricular-vascular coupling efficiency in young aerobic (AT) and resistance (RT) trained athletes. We also investigated the relationship of muscle sympathetic nerve activity (MSNA) and flow mediated dilation (FMD) to AIx in this population to determine if endothelial function or sympathetic outflow could explain any observed differences in arterial stiffness. To accomplish these objectives, we measured MSNA in 15 male subjects (8 RT, 7 AT) using microneurography. We also used applanation tonometry of the radial pressure waveform to noninvasively synthesize aortic pressure waveforms. FMD was calculated as percent dilation of the radial artery from baseline following a 5 minute occlusion. RT subjects had greater AIx (12±3 vs. -7±2; P<0.01), LVEW (429±111 vs. -360±77; P<0.01) and MSNA burst incidence (34±4 vs. 26±4; P<0.01) when compared to AT subjects. There was no significant difference of FMD between groups. MSNA burst incidence was also significantly related to AIx in all subjects (P<0.01) with a distinct demarcation between RT and AT subjects. These results confirm a positive association between MSNA and AIx in young males. Furthermore, RT is associated with increased arterial stiffness and elevated sympathetic outflow.
Steven Devor, T (Advisor)
Robert Hamlin, L (Committee Member)
Charles Buffington, T (Committee Member)
170 p.
Physiology
exercise; aerobic; strength; autonomic; cardiovascular; endothelial; sympathetic; MSNA; arterial stiffness

Recommended Citations

Citations

  • Smith, M. M. (2012). Effects of Neural Sympathetic Nerve Activity and Endothelial Function on Ventriculovascular Coupling Efficiency in Resistance and Endurance Trained Athletes [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1335984673

    APA Style (7th edition)

  • Smith, Michael. Effects of Neural Sympathetic Nerve Activity and Endothelial Function on Ventriculovascular Coupling Efficiency in Resistance and Endurance Trained Athletes. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1335984673.

    MLA Style (8th edition)

  • Smith, Michael. "Effects of Neural Sympathetic Nerve Activity and Endothelial Function on Ventriculovascular Coupling Efficiency in Resistance and Endurance Trained Athletes." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1335984673

    Chicago Manual of Style (17th edition)

osu1335984673
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.