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Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions

Ma, Zhiwei
http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205

Abstract Details

2012, Master of Science, Ohio State University, Biophysics.
Molecular screen methods such as microarrays have been used to identify molecular signatures and biological processes important for particular neuronal functions. This thesis applied a weight gene co-expression network analysis algorithm, edge-covering Quasi-Clique Merger algorithm (eQCM), on human brain microarray data from the Allen Institute of Brain Science. One thousand and sixty-six (1066) gene modules were identified. Within these 1066 gene modules, using eigengene as the representation of each gene module, 46 gene modules with significant p-values were selected by comparing the gene expression profiles between the hippocampus, parahippocampal gyrus and basal ganglia in the human brain. Through gene ontology enrichment analysis, 10 out of these 46 gene modules are significantly engaged in several biological processes of neuronal functions. The results showed that the correlation between molecular similarities and spatial proximity still exists in some human brain regions other than the neocortex.
Kun Huang, Ph.D. (Advisor)
Raghu Machiraju, Ph.D. (Committee Member)

Recommended Citations

Citations

  • Ma, Z. (2012). Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205

    APA Style (7th edition)

  • Ma, Zhiwei. Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions. 2012. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205.

    MLA Style (8th edition)

  • Ma, Zhiwei. "Detecting Gene Modules Differentially Expressed in Multiple Human Brain Regions." Master's thesis, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1339717205

    Chicago Manual of Style (17th edition)

osu1339717205
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.