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Schneider_Christine_Masters_Thesis.pdf (1.19 MB)

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Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses

Schneider, Christine Pariseau
http://rave.ohiolink.edu/etdc/view?acc_num=osu1364991994

Abstract Details

, Master of Science, Ohio State University, Veterinary Clinical Sciences.
Objective: To determine the potency (percent analgesia), duration of action (up to four months), and clinical and histological effects of surgical exposure and intra-neural injection of 98% dehydrated medical-grade ethyl alcohol compared to no treatment (negative control), sham operation (surgical control), or formaldehyde injection (positive control) to decrease experimentally-induced palmar heel pain in horses. Animals: Six horses Procedures: The horses were fitted with a custom pressure-inducing shoe and had outcome measurements for each heel performed before and after nerve treatments. Outcomes included induced lameness grade and vertical peak force with pressure applied to each heel, thermal and touch sensation for each heel, and pastern circumference. Outcomes were followed serially for 112 days when nerves were harvested for histology. Results: Alcohol and formaldehyde reduced all measures of heel pain which progressed toward return, but persisted over the 112 days of the study (P<0.05). Pastern circumference was not different for alcohol than sham treatment, but was greater in formaldehyde than alcohol or baseline (P<0.05). Histological evaluation showed preservation of nerve fiber alignment with an intact epineurium, loss of axons (axon drop out), axon degeneration, fibrosis and inflammation in alcohol- and formaldehyde-injected nerves compared to control nerves. Formaldehyde injection induced greater fibrosis and inflammation than alcohol. Conclusions and Clinical Relevance: Alcohol injection induced effective neural blockade for months with evidence that nerve structure and function could return. Formaldehyde injection showed no advantage over alcohol and is not recommended under the conditions of our study due to soft tissue inflammation.
Alicia Bertone (Advisor)
Michael Oglesbee (Committee Member)
Lisa Zekas (Committee Member)
Veterinary Services

Recommended Citations

Citations

  • Schneider, C. P. (n.d.). Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364991994

    APA Style (7th edition)

  • Schneider, Christine. Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1364991994.

    MLA Style (8th edition)

  • Schneider, Christine. "Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses." Master's thesis, Ohio State University. Accessed APRIL 26, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364991994

    Chicago Manual of Style (17th edition)

osu1364991994
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This open access ETD is published by The Ohio State University and OhioLINK.