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Alex_Marras_MS_Thesis.pdf (46.79 MB)

ETD Abstract Container

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DNA Origami Mechanisms and Machines

Marras, Alexander Edison
http://orcid.org/0000-0001-8972-9532
http://rave.ohiolink.edu/etdc/view?acc_num=osu1366227349

Abstract Details

2013, Master of Science, Ohio State University, Mechanical Engineering.
This thesis establishes scaffolded DNA origami as a viable approach to designing and fabricating nanoscale mechanisms and machines. The work presented shows a fundamental proof-of-concept for the fabrication of DNA Origami Mechanisms and Machines (DOMM). The scope of the project is to design, fabricate, and analyze DNA origami joints, incorporate them into larger mechanisms, and actuate the mechanisms. This thesis starts with the initial step of creating DNA origami revolute joints (hinges). Revolute joints are single degree of freedom joints and demonstrate the design and construction of nanoscale kinematic joints with specific constrained motion. The revolute joint design was integrated into a DNA origami Bennett 4-bar mechanism. This mechanism has a 3D motion path that is specified by the dimensions of the links and the arrangement of the hinges. The motion of the DNA origami linkage agrees well with its rigid body counterpart. These linkages were further actuated using DNA inputs. This method of actuation proves to be an effective way to control DNA origami mechanisms. The ultimate goal of this project is to develop a library of DNA-based links and joints that can be widely used in the design and assembly of higher order controllable nanomachines. This work has the potential of initiating a new era of nanorobot design useful for applications including drug delivery, biosensing, and nanomanufacturing.
Carlos Castro (Advisor)
Haijun Su (Committee Member)
96 p.
Biomedical Engineering; Design; Engineering; Mechanical Engineering
DNA origami; DNA nanotechnology; nanorobot; design; nanomachine; DNA origami mechanisms and machines; DOMM; NBL; Nanoengineering and Biodesign Lab; Marras;

Recommended Citations

Citations

  • Marras, A. E. (2013). DNA Origami Mechanisms and Machines [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366227349

    APA Style (7th edition)

  • Marras, Alexander. DNA Origami Mechanisms and Machines. 2013. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1366227349.

    MLA Style (8th edition)

  • Marras, Alexander. "DNA Origami Mechanisms and Machines." Master's thesis, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366227349

    Chicago Manual of Style (17th edition)

osu1366227349
377
© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.