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The Role of ASIC1a in The Regulation of Synaptic Release Probability

Culver, Soluman B
http://rave.ohiolink.edu/etdc/view?acc_num=osu1366816804

Abstract Details

2013, Master of Science, Ohio State University, Pathology.
Extracellular pH plays an important role in neuronal signaling. As primary receptors of pH signals, acid-sensing ion channels (ASICs) are able to translate fluctuations in the extracellular pH into membrane potentials and calcium signals. ASICs and pH signaling are thought to play important roles in anxiety, affect, and pain, although the mechanism by which they are able to influence these processes remains poorly understood. During conditions of dysregulated pH aberrant ASIC activity is known to result in cellular dysfunction and death, making a mechanistic explanation of ASIC function of broad importance to our understanding of downstream consequences during pathophysiological circumstances. One significant role of ASIC is in its ability to modulate synaptic vesicle release, a property which may contribute to neuronal dysfunction secondary to disruptions in pH signaling. This study demonstrates that the mechanism of ASIC-dependent regulation of synaptic vesicle does not rely upon rapid local signaling, but rather requires several hours of ASIC block to be interrupted, suggesting that it may take place through the induction of gene regulation and cause global changes in cellular physiology. Similarly, our results suggest that ASIC1a may be responding to endogenous proton flux to accomplish this regulation, refining our understanding of the cause and context of ASIC1a activation in health and disease.
James Waldman, PhD (Advisor)
Candice Askwith, PhD (Committee Member)
John Enyeart, PhD (Committee Member)
57 p.
Neurosciences; Pathology; Physiology
Ion channels; electrophysiology; acid; acid-sensing ion channels; pathology

Recommended Citations

Citations

  • Culver, S. B. (2013). The Role of ASIC1a in The Regulation of Synaptic Release Probability [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366816804

    APA Style (7th edition)

  • Culver, Soluman. The Role of ASIC1a in The Regulation of Synaptic Release Probability. 2013. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1366816804.

    MLA Style (8th edition)

  • Culver, Soluman. "The Role of ASIC1a in The Regulation of Synaptic Release Probability." Master's thesis, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366816804

    Chicago Manual of Style (17th edition)

osu1366816804
140
© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.