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Trauma and Cytokines: Gingival Crevicular Fluid Biomarkers in Traumatized Permanent Incisors - A Pilot Investigation

Rosenvall, Christopher G
http://rave.ohiolink.edu/etdc/view?acc_num=osu1372003396

Abstract Details

2013, Master of Science, Ohio State University, Dentistry.
Extensive research has yielded unpredictable long-term results for traumatized teeth. While epidemiological research in the area of treatment of traumatized teeth is well documented, descriptive studies focusing on biological predictors of healing are non-existent. The objective of this study is to determine if any variation exists between normal healing and pathology in traumatized teeth in growing children that could lead to early predictors of pathology. This could ultimately help to decrease cost and time for patients and their families. In order to determine a baseline of biomarkers of traumatized teeth, we retrospectively examined cytokine levels in gingival crevicular fluid (GCF) following trauma of permanent mature anterior teeth in growing children. GCF was collected from each injured tooth and a non-injured control tooth in the same arch. Injured teeth were categorized as displaced or non-displaced injuries. A total of 48 injured teeth from 34 patients were examined. 27 cytokines were analyzed, and levels of cytokines were found to be significantly different in injured teeth compared to control teeth. Additionally, levels of specific cytokines were significantly higher in displaced teeth compared to non-displaced injuries. The results of this study lay a foundation for further studies that can provide information for a possible early test to predict healing of traumatized teeth.
Dennis McTigue (Advisor)
Kumar Subramanian (Committee Member)
Purnima Kumar (Committee Member)
72 p.
Dentistry

Recommended Citations

Citations

  • Rosenvall, C. G. (2013). Trauma and Cytokines: Gingival Crevicular Fluid Biomarkers in Traumatized Permanent Incisors - A Pilot Investigation [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372003396

    APA Style (7th edition)

  • Rosenvall, Christopher. Trauma and Cytokines: Gingival Crevicular Fluid Biomarkers in Traumatized Permanent Incisors - A Pilot Investigation. 2013. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1372003396.

    MLA Style (8th edition)

  • Rosenvall, Christopher. "Trauma and Cytokines: Gingival Crevicular Fluid Biomarkers in Traumatized Permanent Incisors - A Pilot Investigation." Master's thesis, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372003396

    Chicago Manual of Style (17th edition)

osu1372003396
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© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.