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Dissertation - Anthony Duong.pdf (3.4 MB)

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Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles

Duong, Anthony David
http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508

Abstract Details

2013, Doctor of Philosophy, Ohio State University, Chemical and Biomolecular Engineering.
Remarkable developments in pharmaceuticals, immunology and imaging have expedited progress toward the goal of more efficient, targeted therapeutics and diagnostics. Currently, there is a need for improved production methods for microparticles and nanoparticles that are used as delivery vehicles for active agents in these fields. Many types of delivery vehicles have been developed using polymer and lipid particles to encapsulate the desired cargo. However, most particle production methods rely on complex, multi-step, batch processes that generally involve liquid phase mixing and emulsions. Although these methods may be appropriate on some laboratory scales, new methods must be investigated to transfer many particle-based technologies to clinical and industrial settings. Electrohydrodynamic spray (electrospray) is an inexpensive, continuous, single step, aerosol route to producing such particles. We have demonstrated the successful application of electrospray to the production of three types of delivery vehicles: solid polymer microparticles, block copolymer micelles and liposomes. First, electrospray was shown to improve the encapsulation efficiency of an immune modulating drug in acetalated dextran microparticles. Furthermore, the encapsulated drug showed improved bioactivity over the free drug. Second, coaxial electrospray was investigated as a method of high scale production of magnetic-fluorescent micelles used for imaging and manipulation of cancer cells. The particles were comparable to those produced using an emulsion approach, but could be produced semi-continuously and in much higher quantities. Moreover, these particles were used for the detection and separation of cancer cells in vitro. Thirdly, coaxial electrospray was applied to the encapsulation of small molecular drugs in liposomes. A process is described in which liposomal encapsulation efficiency may be increased while drastically reducing the number of process steps and time required. Electrospray has the potential to improve encapsulation efficiencies of drugs in polymer and lipid particles. Moreover, it can be operated continuously and scaled up. The use of electrospray in production of biomedical delivery vehicles is still relatively new and there are many unexplored applications of this technology. As a result, there is a substantial amount of work remaining in this field. Although it is not the only new particle production method under development, electrospray has the potential to aid in the fabrication many types of particles that have desirable encapsulation, targeting and release capabilities, while accelerating the transition of these particles from the lab to their ultimate clinical and industrial applications.
Barbara Wyslouzil (Advisor)
Kristy Ainslie (Committee Member)
Jessica Winter (Committee Member)
220 p.
Biomedical Engineering; Cellular Biology; Chemical Engineering; Immunology; Nanoscience; Nanotechnology; Polymers
Electrospray, Nanoparticle, Drug Delivery, Cell Detection

Recommended Citations

Citations

  • Duong, A. D. (2013). Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508

    APA Style (7th edition)

  • Duong, Anthony. Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles. 2013. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508.

    MLA Style (8th edition)

  • Duong, Anthony. "Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles." Doctoral dissertation, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508

    Chicago Manual of Style (17th edition)

osu1376913508
371
© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.