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Comparison of Effects of Daily and Pulse Dose Calcitriol in Treating Renal Secondary Hyperparathyroidism in Cats with Primary Chronic Renal Failure

Hostutler, Roger Allen
http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282849

Abstract Details

2004, Master of Science, Ohio State University, Veterinary Clinical Sciences.
The primary objective of this study was to determine the efficacy of calcitriol in controlling renal secondary hyperparathyroidism in cats with naturally-occurring chronic renal failure (CRF). Other objectives included comparing the effectiveness of daily versus pulse dose (every 84 hours) calcitriol in controlling renal secondary hyperparathyroidism and evaluating for adverse effects of calcitriol administration, primarily hypercalcemia. Two groups of cats were studied. The groups consisted of 10 normal cats and 10 cats with CRF. Normal cats were defined as those having no azotemia (abnormally high blood urea nitrogen or serum creatinine concentrations), negative urine culture on urine obtained by cystocentesis, and normal physical examination. Cats with CRF were included if abnormally high serum creatinine concentration, >1.8 mg/dL and <5.0 mg/dL, and isosthenuria were present, and if serum phosphorus concentration was <6.0 mg/dL. Both groups of cats were treated in an identical manner. Before beginning the study, baseline data including packed cell volume, total protein concentration, serum biochemistry, urinalysis, urine culture on urine obtained by cystocentesis, serum ionized calcium concentration, serum parathyroid hormone (PTH) concentration, and serum calcitriol concentration were obtained. In the first phase of the study, each cat was given calcitriol at a dosage of 2.5 ng/kg daily for 14 days. After a 14 day washout period, the second phase of the study was started and each cat was given calcitriol at a dosage of 8.75 ng/kg every 84 hours (h). On days 1, 2, and 3 after starting calcitriol during each phase, serum ionized calcium concentration was determined to identify development of hypercalcemia. On day 14 of each phase, serum concentrations of ionized calcium, calcitriol, and PTH were determined before calcitriol administration (time 0), and 2, 4, and 6h after calcitriol administration. PTH concentrations were significantly higher in the CRF group when compared to the normal group of cats at the beginning of the study. Serum PTH concentrations decreased in both groups of cats during both phases of the study. At the end of phase 1, PTH concentration had decreased significantly in the CRF cats when compared to values obtained before enrollment in the study. In the CRF group, serum PTH concentration at the end of phase 2 was identical to the value obtained at the end of phase 1. Calcitriol administration appeared to help alleviate renal secondary hyperparathyroidism regardless of the dosage regimen used. Further study is warranted to determine optimal dosage and to evaluate the use of pulse dosing in CRF cats with a maximally hyperplastic parathyroid glands. Hypercalcemia, a potential complication of calcitriol administration, was not observed in any cat throughout the study period with either dosage protocol.
Stephen P. DiBartola (Advisor)
Dennis J. Chew (Committee Member)
W. Tod Drost (Committee Member)
Larry Nagode (Committee Member)
40 p.
Veterinary Services

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Citations

  • Hostutler, R. A. (2004). Comparison of Effects of Daily and Pulse Dose Calcitriol in Treating Renal Secondary Hyperparathyroidism in Cats with Primary Chronic Renal Failure [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282849

    APA Style (7th edition)

  • Hostutler, Roger. Comparison of Effects of Daily and Pulse Dose Calcitriol in Treating Renal Secondary Hyperparathyroidism in Cats with Primary Chronic Renal Failure. 2004. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282849.

    MLA Style (8th edition)

  • Hostutler, Roger. "Comparison of Effects of Daily and Pulse Dose Calcitriol in Treating Renal Secondary Hyperparathyroidism in Cats with Primary Chronic Renal Failure." Master's thesis, Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282849

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.