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Maximizing the max test: Development of a maximal graded exercise test for the assessment of cardiovascular function in mice

Petrosino, Jennifer M
http://rave.ohiolink.edu/etdc/view?acc_num=osu1428595054

Abstract Details

2015, Master of Science, Ohio State University, Kinesiology.
Tools for the functional assessment of cardiovascular fitness are needed to establish animal models of dysfunction and the effects of novel therapeutics. Currently, exercise assays are widely published; however, they have limited sensitivity for assessing the cardio-metabolic phenotype of mice. In human research, the graded maximal exercise test (GXT) is a gold standard diagnostic for measuring cardiovascular function. Present published testing methods in mice use set inclination and progressive increases in speed until exhaustion (PXT); thus lacking characteristics of the GXT. We developed a GXT test that allows for assessment of cardiovascular fitness in metabolic and genetic models of cardiovascular dysfunction; as well as in healthy mice. The results of comparison between this method and the PXT revealed that only the GXT test provides sensitive, quantitative, parameters for diagnosing and monitoring cardiovascular, metabolic and pulmonary function in mouse models.
Ouliana Ziouzenkova, Dr. (Advisor)
Brian Focht, Dr. (Advisor)
Denis Guttridge , Dr. (Committee Member)
77 p.
Kinesiology
Cardiovascular disease, exercise, diabetes, heart failure, metabolic disease, protocol, obesity, VO2max, testing, physiology, metabolism

Recommended Citations

Citations

  • Petrosino, J. M. (2015). Maximizing the max test: Development of a maximal graded exercise test for the assessment of cardiovascular function in mice [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428595054

    APA Style (7th edition)

  • Petrosino, Jennifer. Maximizing the max test: Development of a maximal graded exercise test for the assessment of cardiovascular function in mice. 2015. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1428595054.

    MLA Style (8th edition)

  • Petrosino, Jennifer. "Maximizing the max test: Development of a maximal graded exercise test for the assessment of cardiovascular function in mice." Master's thesis, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428595054

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.