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A Mathematical Model of Cytokinetic Morphogenesis.pdf (1.91 MB)
ETD Abstract Container
Abstract Header
A Mathematical Model of Cytokinetic Morphogenesis
Author Info
Anderson, Kerri-Ann
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1429607984
Abstract Details
Year and Degree
2015, Master of Mathematical Sciences, Ohio State University, Mathematics.
Abstract
Cytokinesis occurs through coordinated biochemical processes that result in biophysical stresses that act on the cytoskeleton. In order to uncover the physical mechanisms responsible for the cytokinetic behavioral differences between normal and abnormal cells, we use computational methods to simulate the effects of varying these physical mechanisms; our methods are applied to both deterministic and stochastic models. Particularly in non-adhesive conditions, it has been observed that Myosin II Contractile Force is the major driving force of furrow ingression. Modification of the maximum myosin stress parameter, the myosin distribution and cell elasticity achieved results that coincide with other findings and biological inferences about cell behavior. The model presented in this report provides a preliminary basis for future quantitative identification of abnormal cells, and the identification of possible cancer therapeutic targets. Via this model we are able to gain further understanding of the bio-mechanical properties of cells and their effects on cytokinesis.
Committee
Ching-Shan Chou, PhD (Advisor)
Adriana Dawes, PhD (Committee Member)
Pages
39 p.
Subject Headings
Biology
;
Mathematics
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Citations
Anderson, K.-A. (2015).
A Mathematical Model of Cytokinetic Morphogenesis
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429607984
APA Style (7th edition)
Anderson, Kerri-Ann.
A Mathematical Model of Cytokinetic Morphogenesis.
2015. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1429607984.
MLA Style (8th edition)
Anderson, Kerri-Ann. "A Mathematical Model of Cytokinetic Morphogenesis." Master's thesis, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429607984
Chicago Manual of Style (17th edition)
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Document number:
osu1429607984
Download Count:
713
Copyright Info
© 2015, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.