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Brandon Glenn Thesis.pdf (2.32 MB)

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EVALUATION OF EXPAREL® FOR POSTOPERATIVE PAIN/NUMBNESS IN SYMPTOMATIC TEETH WITH A PULPAL DIAGNOSIS OF NECROSIS

Glenn, Brandon Norman
http://rave.ohiolink.edu/etdc/view?acc_num=osu1437137510

Abstract Details

2015, Master of Science, Ohio State University, Dentistry.
Medical studies have shown the potential for liposomal bupivacaine, an injected slow-release bupivacaine solution, to extend the postoperative benefits of numbness for up to several days. The purpose of this study was to compare bupivacaine to liposomal bupivacaine (Exparel®) for postoperative numbness and pain in symptomatic patients diagnosed with pulpal necrosis experiencing moderate to severe preoperative pain. One hundred patients were treated with endodontic debridement, antibiotics, and given a supply of ibuprofen (600 mg) and acetaminophen (1000 mg). Patients were prescribed narcotic pain medication as needed for pain. Patients were randomly divided into two groups. At the end of the appointment patients received a 4.0 ml buccal infiltration of either 0.5% bupivacaine or Exparel®. Patients recorded their level of numbness and pain over the next five days, as well as pain medication utilization. Success was defined as no or mild postoperative pain (=54 mm on a 170-mm visual analog scale) and no narcotic use. Success was analyzed using the chi-square test. The success rate was 29% for the Exparel® group and 22% for the bupivacaine group, with no significant difference (P = .4684) between the groups. Patients in the Exparel® group reported significantly more soft tissue numbness through postoperative Day 2, while tooth numbness was not significantly different. For patients diagnosed with pulpal necrosis experiencing mild to moderate preoperative pain, a 4.0 ml infiltration of Exparel® following endodontic debridement did not result in a statistically significant increase in success compared with bupivacaine.
Melissa Drum, DDS, MS (Advisor)
164 p.
Dentistry
Exparel; bupivacaine; endodontic; postoperative pain; pulpal necrosis

Recommended Citations

Citations

  • Glenn, B. N. (2015). EVALUATION OF EXPAREL® FOR POSTOPERATIVE PAIN/NUMBNESS IN SYMPTOMATIC TEETH WITH A PULPAL DIAGNOSIS OF NECROSIS [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437137510

    APA Style (7th edition)

  • Glenn, Brandon. EVALUATION OF EXPAREL® FOR POSTOPERATIVE PAIN/NUMBNESS IN SYMPTOMATIC TEETH WITH A PULPAL DIAGNOSIS OF NECROSIS. 2015. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1437137510.

    MLA Style (8th edition)

  • Glenn, Brandon. "EVALUATION OF EXPAREL® FOR POSTOPERATIVE PAIN/NUMBNESS IN SYMPTOMATIC TEETH WITH A PULPAL DIAGNOSIS OF NECROSIS." Master's thesis, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437137510

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.