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Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications

Das, Amitava
http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458

Abstract Details

2016, Doctor of Philosophy, Ohio State University, Nutrition Program, The Ohio State University.
Metabolic syndrome is a combination of metabolic disorders like dyslipidemia, high blood pressure, impaired glucose tolerance and abdominal fat accumulation. Metabolic syndrome leads to an increased risk of developing cardiovascular disease and is a major public concern all over the world. Overweightedness and obesity are important features of metabolic syndrome which is characterized by systemic and tissue specific chronic inflammation and may lead to the development of the obesity-related co-morbidities like type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Persistent hyperglycemia in T2DM cases generally lead to the development of secondary complications including neuropathy, nephropathy, retinopathy, peripheral vascular diseases, cerebrovascular diseases and impaired wound healing. Dysregulated inflammatory response during T2DM leads to non-resolving chronic wounds which is a major threat to the society. This dissertation aims to elucidate the molecular mechanisms underlying the dysregulated inflammatory response in diabetes. This study offers a new paradigm in inflammation as it addresses a basic and fundamental cellular mechanism for resolution of wound inflammation. The work is likely to shed light in inflammatory disorders as a whole, above and beyond applications to wound settings. In addition nutritional interventions of ameliorating metabolic complications in obese and overweight subjects have been addressed in this dissertation.
Sashwati Roy, PhD (Advisor)
Savita Khanna, PhD (Committee Member)
Chandan Sen, PhD (Committee Member)
Gayle Gordillo, PhD (Committee Member)
Cameron Rink, PhD (Committee Member)
188 p.
Immunology; Nutrition

Recommended Citations

Citations

  • Das, A. (2016). Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458

    APA Style (7th edition)

  • Das, Amitava. Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458.

    MLA Style (8th edition)

  • Das, Amitava. "Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458

    Chicago Manual of Style (17th edition)

osu1461254458
559
© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.