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Design, Fabrication, and Characterization of Electroceutical Bandages for Treatment of Chronically Infected Wounds

Bennett, Molly Marie, Bennett
http://rave.ohiolink.edu/etdc/view?acc_num=osu1462837586

Abstract Details

2016, Master of Science, Ohio State University, Mechanical Engineering.
In the United States, 6.5 million patients are affected by chronic wounds, sometimes complicated by infection. If the bacteria form a biofilm at the wound site, treatment of the infection becomes significantly more difficult. Biofilm bacteria are 500 to 5,000 times more resistant to antibiotic medications than the non-biofilm bacteria. Previous studies have shown that the presence of direct electric current through the biofilm enhances the activity of various antibiotics against biofilm-forming bacterial strains such as Pseudomonas aeruginosa and Staphylococcus epidermidis. This behavior has been referred to as the electro-bactericidal effect. A large parametric investigation with various substrates, conductive patterns, and designs has led to a novel electroceutical bandage comprised of a silver-based ink on silk fabric, connected to a 6 V DC battery source and switch circuit for easy operation. The electroceutical bandage was characterized by tests using the bacterial strain Pseudomonas aeruginosa to test the efficacy of biofilm inhibition. The results showed that this dressing successfully and repeatedly prevents the bacteria from forming a biofilm, as well as excludes bacteria from the anode of the bandage. It is noteworthy that use of an isolated electrode system i.e., electric field applied to the bacteria without direct flow of current through the bacterial layers, did not yield inhibition of the biofilm formation. Therefore, mechanistically, one may expect oxidation reactions at the anode to be important. Further in vitro tests studying the effects of the bandage on pre-formed biofilms grown for 24 and 48 hours prior to testing have shown diminished bacteria growth as well. This electroceutical bandage could prevent infection from developing at the wound site, as well as help treat existing infections. Severe biofilm infection can lead to amputation to prevent spread of infection. If more reliable and successful means of treating biofilm infections can be implemented, complications of chronic wounds will be reduced.
Shaurya Prakash (Advisor)
Vish Subramaniam (Committee Member)
165 p.
Mechanical Engineering; Surgery
electroceutical; bandage; biofilm;

Recommended Citations

Citations

  • Bennett, Bennett, M. M. (2016). Design, Fabrication, and Characterization of Electroceutical Bandages for Treatment of Chronically Infected Wounds [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462837586

    APA Style (7th edition)

  • Bennett, Bennett, Molly. Design, Fabrication, and Characterization of Electroceutical Bandages for Treatment of Chronically Infected Wounds. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1462837586.

    MLA Style (8th edition)

  • Bennett, Bennett, Molly. "Design, Fabrication, and Characterization of Electroceutical Bandages for Treatment of Chronically Infected Wounds." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462837586

    Chicago Manual of Style (17th edition)

osu1462837586
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© 2016, some rights reserved.Creative Commons License Design, Fabrication, and Characterization of Electroceutical Bandages for Treatment of Chronically Infected Wounds by Molly Marie Bennett Bennett is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.